Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024614
pages 1071-1081

Blood Glucose–Reducing and Fat-Reducing Effects of a Novel Medicinal Mushroom, Grifola gargal (Agaricomycetes)

Etsuko Harada
Department of Immunology, Mie University School of Medicine
Toshihiro Morizono
Department of Immunology, Mie University School of Medicine, Tsu, Mie, Japan
Masayoshi Saito
Department of Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan


Grifola gargal Singer is a medicinal mushroom with biological effects such as antiatherogenic and antiosteoporotic activities. The objective of this study was to examine a blood glucose–reducing effect and a fatreducing effect of G. gargal supplementation in vivo. The effects of G. gargal powder (GGP) in a high–molecular weight hot water extract (GGH) and a low–molecular weight hot water extract (GGL) on blood glucose were investigated in streptozotocin (STZ)-induced diabetic ICR mice (STZ diabetic mice). A significant decrease in blood glucose was observed after 5 weeks of GGL supplementation (fraction with a molecular weight ≤ 6000 Da) in STZ diabetic mice. In the next test, we examined the antihyperglycemic and fat-reducing effects of GGL in diet-induced obesity (DIO) mice fed a high-fat diet. GGL facilitated reductions in blood glucose and body fat. This study confirms, to our knowledge for the first time, that administration of G. gargal extract has antihyperglycemic and body fat–reducing effects in STZ diabetic mice and DIO mice. Therefore, G. gargal is a promising functional food to prevent and treat diabetes and lifestyle-related diseases.

Articles with similar content:

Protective Effect of Acacia ferruginea against Ulcerative Colitis via Modulating Inflammatory Mediators, Cytokine Profile and NF-κB Signal Transduction Pathways
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Chandrasekaran Guruvayoorappan, Kunnathur Murugesan Sakthivel
Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): A Species with Antioxidant, Immunomodulatory, and Hepatoprotective Activities in Hypercholesterolemic Rats
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 11
Haseeb Anwar, Jaweria Nisar, Ghulam Hussain, Shazia Anwer Bukhari, Muhammad Naeem Faisal, Muhammad Irfan Ullah, Abdul Basit, Imtiaz Mustafa, Muhammad Umar Sohail
Antidiabetic Properties of the Tiger's Milk Medicinal Mushroom, Lignosus rhinocerotis (Agaricomycetes), in Streptozotocin-Induced Diabetic Rats
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 7
Szu Ting Ng, Cheng Fhai Chow, Chon Seng Tan, Kar Lin Nyam
Ethanolic Extract of the Golden Oyster Mushroom, Pleurotus citrinopileatus (Agaricomycetes), Alleviates Metabolic Syndrome in Diet-Induced Obese Mice
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 11
Changhui Zhao, Quanbo Chi, Kunlun Huang, Pengfei Shi, Guoyi Wang, Yao Sheng, Wentao Xu
Improvement of Nutritional and Bioactive Compound Production by Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), by Spraying Growth Regulators
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 3
Rui'an Chen, Jun-fang Lin, Minhthuan Vi, Qianwang Zheng, Tao Wei, Qianyun He, Xianlu Zeng, Li-qiong Guo, Xueqin Yang