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International Journal of Medicinal Mushrooms

Impact factor: 1.357

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i9.10
pages 757-767

Pharmacological Properties of Biocompounds from Spores of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes): A Review

Carlos Ricardo Soccol
Department of Bioprocess Engineering and Biotechnology, Federal University of Parana, Curitiba, Parana, Brazil
Lucas Yamasaki Bissoqui
Department of Bioprocess Engineering and Biotechnology, Federal University of Parana, Curitiba, Parana, Brazil
Cristine Rodrigues
Department of Bioprocess Engineering and Biotechnology, Federal University of Parana, Curitiba, Parana, Brazil
Rosalia Rubel
Hospital de Clinicas, Federal University of Parana, Curitiba, Parana, Brazil
Sandra R.B.R. Sella
Center for the Production of and Research into Immunobiological Products, Parana State Department of Health, Piraquara, PR, Brazil
Fan Leifa
Institute of Horticulture, Academy of Agronomy Sciences of Zhejiang, Hangzhou, Zhejiang Province, China
Luciana Porto de Souza Vandenberghe
Department of Bioprocess Engineering and Biotechnology, Federal University of Parana, Curitiba, Parana, Brazil
Vanete Thomaz Soccol
Department of Bioprocess Engineering and Biotechnology, Federal University of Parana, Curitiba, Parana, Brazil

ABSTRACT

Ganoderma lucidum is a well-known representative of mushrooms that have been used in traditional Chinese medicine for centuries. New discoveries related to this medicinal mushroom and its biological properties are frequently reported. However, only recently have scientists started to pay special attention to G. lucidum spores. This is in part because of the recent development of methods for breaking the spore wall and extracting biocompounds from the spore. Although some research groups are working with G. lucidum spores, data in the literature are still limited, and the methods used have not been systematized. This review therefore describes the main advances in techniques for breaking the spore wall and extracting biocompounds from the spore. In addition, the major active components identified and their biological properties, such as neurological activity and antiaging and cell-protective effects, are investigated because these are of importance for potential drug development.