Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024413
pages 879-892

Water-Soluble Polysaccharide Extracts from the Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory Activity

Alicia Gil-Ramirez
Department of Production and Characterization of Novel Foods, CIAL–Research Institute in Food Science, Universidad Autónoma de Madrid, Madrid, Spain
Fhernanda R. Smiderle
Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Parana, Brazil
Diego Morales
Department of Production and Characterization of Novel Foods, CIAL–Research Institute in Food Science, Universidad Autónoma de Madrid, Madrid, Spain
Coen Govers
Food & Biobased Research, Wageningen University and Research Centre, Wageningen, The Netherlands
Andriy Synytsya
Department of Carbohydrates and Cereals, Institute of Chemical Technology, Prague, Czech Republic
Harry J. Wichers
Food & Biobased Research, Wageningen University and Research Centre, Wageningen, The Netherlands
Marcello Iacomini
Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Parana, Brazil
Cristina Soler-Rivas
Department of Production and Characterization of Novel Foods, CIAL–Research Institute in Food Science, Universidad Autónoma de Madrid, Madrid, Spain

ABSTRACT

Water extracts from Pleurotus ostreatus containing no statins showed 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCR) inhibitory activity (in vitro) that might be due to specific water-soluble polysaccharides (WSPs); when isolated and deproteinized, increasing concentrations of the WSP extract induced higher inhibition. The WSP extract contained mainly β-glucans, mannogalactans, and glycogen (e.g., α-glucans), although derivatives or fragments with lower molecular weights (between 14 and 3.5 kDa) were present and were able to induce the inhibitory activity. The extract contained more β-(1→3)-glucans than β-(11→3),(11→6)-glucans, and they partially survived digestion and managed to pass through Caco2 cell monolayers to the lower compartment after in vitro digestion and transport experiments. The WSP might also modulate Caco2 membrane integrity.


Articles with similar content:

Characterization of Cross-Flow Ultrafiltration Fractions from Maitake Medicinal Mushroom, Grifoia frondosa (Agaricomycetes), Reveals Distinct Cytotoxicity in Tumor Cells
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 8
Miriam Sari, Nicole Teusch, Katharina Toepler, Jan I. Lelley, Anna Nickisch-Hartfiel, Reinhard Hambitzer
High-Level Production of Exopolysaccharides by a Cosmic Radiation−Induced Mutant M270 of the Maitake Medicinal Mushroom, Grifola frondosa (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 7
Ai-Rong Song, Chen Zhao, Wen-Xing Liang, Guang-Yuan Wang, Xue-Mei Tian
Production of Ginkgo Leaf−Shaped Basidiocarps of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes), Containing High Levels of α- and β-D-Glucan and Ganoderic Acid A
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 2
Tamotsu Hoshino, Minoru Miyazaki, Yuka Yajima, Noriyasu Okita
Anticonvulsant and Neuroprotective Effects of Oligosaccharides from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes)
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 6
Isaac Tello, Victoria Campos-Pena, Elizur Montiel-Arcos, Veronica Rodriguez, Alma Aguirre-Moreno, Ismael Leon-Rivera, Federico del Rio-Portilla, Maribel Herrera-Ruiz, Juana Villeda-Hernandez
Submerged and Solid-State Cultivation of Bioactive Extra- and Intracellular Polysaccharides of Medicinal Mushrooms Ganoderma lucidum (W. Curt.: Fr.) P. Karst. and Grifola frondosa (Dicks.: Fr.) S. F. Gray (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 4
Branka Wraber, Jozica Habijanic, Mirjan Svagelj, Bojana Boh, Marin BEROVIC