Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024564
pages 905-913

A Primary Study of the Antioxidant, Hypoglycemic, Hypolipidemic, and Antitumor Activities of Ethanol Extract of Brown Slimecap Mushroom, Chroogomphus rutilus (Agaricomycetes)

Jinxiu Zhang
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Xiaojing Zhao
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Li Qiang Zhao
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Junxia Zhao
The Basic Medical College, Hebei Medical University, Shijiazhuang, People's Republic of China
Zhiguang Qi
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China
Li-An Wang
The Life Science College, Hebei Normal University, Shijiazhuang, People's Republic of China

ABSTRACT

In vivo and in vitro treatments were carried out to investigate the effects of a 95% ethanol extract of Chroogomphus rutilus (CRE) on antioxidant, hypoglycemic, hypolipidemic, and antitumor properties. CRE showed potent radical scavenging activity against DPPH in vitro. It could increase antioxidant enzymatic activities (superoxide dismutase and glutathione peroxidase) and could reduce malondialdehyde content in vivo in mice in which aging was induced by D-galactose. CRE had hypoglycemic activity and could significantly inhibit α-glucosidase activity in vitro and decrease blood glucose concentration in vivo. CRE could decrease the serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels and increase the high-density lipoprotein cholesterol level in diabetic mice. The MTT assay showed that CRE also had a certain inhibitory effect on the tumor cells. These results suggest that CRE may be beneficial for human health and could be useful for applications in medicine, the food industry, and agriculture.


Articles with similar content:

Supplementation of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) Extract Enhanced the Medicinal Values and Prebiotic Index of Hungarian Acacia Honey
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 12
Iman Mirmazloum, Attila Kiss, Erzsébet Némedi, Zoltán Naár
Fermented Pu-erh Tea Increases In Vitro Anticancer Activities in HT-29 Cells and Has Antiangiogenetic Effects on HUVECs
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 4
Jong-Deog Kim, Kun-Young Park, Jong-Suk Lee, Xin Zhao, Jia-Le Song
Evaluation of Anticholinesterase and Inflammation Inhibitory Activity of Medicinal Mushroom Phellinus pini (Basidiomycetes) Fruiting Bodies
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 11
Tae Soo Lee, Jae-hyuk Choi, Jae Kwang Kim, Trung Kien Nguyen, Kyung Hoan Im
Antioxidant Effects of Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes): Evidence from Animal Studies
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 10
Solomon P. Wasser, Nataliya O. Sybirna, Borys Yurkiv, Eviatar D. Nevo
Antioxidant and Antitumor Activities of Cultured Mycelium of Culinary-Medicinal Paddy Straw Mushroom Volvariella volvacea (Bull.: Fr.) Singer (Agaricomycetideae)
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 2
Kainoor K. Janardhanan, Kuttikkadan A. Rony, Thozhuthumparambil P. Smina, Naraycinci P. Sudheesh, John Mathew