Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i11.50
pages 1055-1060

Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes)

Mingxing Wang
Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, China; International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China
Tetsuya Konishi
Affiliated Hospital, Changchun University of Chinese Medicine, Changchun, China; Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Yang Gao
Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Duoduo Xu
International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China
Qipin Gao
International Collaborative Research Center, Changchun University of Chinese Medicine, Changchun, China

ABSTRACT

Hericium erinaceus is a culinary-medicinal mushroom that is used in traditional medicine, in folk medicine, and as medicinal cuisine in Asian countries such as China, Japan, and Korea. H. erinaceus exhibits various pharmacological properties, such as anti-cancer, immunomodulation, anti-dementia, and anti-gastric ulcer effects. The extracts of the fruiting body of H. erinaceus demonstrate anti-gastritis activity. However, the active principle in the extract, as well as the mechanism to treat gastric ulcers, remains uncertain. The current study aims to identify the active component, with anti-gastric ulcer function, from the extracts of the H. erinaceus mycelium culture. In the experiment, anti-gastric ulcer activity was evaluated using an ethanol-induced ulcer model in mice and with an 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay using MC cell lines. The results suggest that the polysaccharide fraction can significantly decrease the ulcerated area compared with the control group and the effect is fairly dose dependent, irrespective of animal or cell experiments. These results indicate that the polysaccharide fraction is the active component of the H. erinaceus mycelium culture, which protects against gastric ulcers.


Articles with similar content:

A Polysaccharide Isolated from Mycelia of the Lion’s Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Induced Apoptosis in Precancerous Human Gastric Cells
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 12
Yanqiu Zhang, Yang Gao, Xulang Xiao, Mingxing Wang, Duoduo Xu, Qipin Gao
Chemopreventive Properties of Mushrooms Against Breast Cancer and Prostate Cancer
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Y.-C. Yuan, K. Lui, J. Ye, G. Hur, D. Smith, S. Chen, S. Phung, S. Kwok, K. Karlsberg, S. Oh
Antioxidant and Antigenotoxicity Activities of Extracts from Liquid Submerged Culture of Culinary-Medicinal Ferula Oyster Mushroom, Pleurotus eryngii (DC.) Quél. var. ferulae (Lanzi) Sacc. (Agaricomycetideae)
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 4
Shu-Ling Hsieh, Juang-Lin Lien, Jinn-Chyi Wang, Shu-Hui Hu, Sue-Joan Chang
Anticancer and Antimicrobial Activities and Chemical Composition of the Birch Mazegill Mushroom Lenzites betulina (Higher Basidiomycetes)
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 4
Qian Wang, Le Zhao, Kun Liu, Jun-Li Wang
Biological Activities of the Polysaccharides Produced from Different Sources of Xylaria nigripes (Ascomycetes), a Chinese Medicinal Fungus
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 2
Mu-Chun Hung, Fang-Yi Lin, Wai-Jane Ho, Zeng-Chin Liang, Tai-Hao Hsu, Shih-Liang Chang, Chia-Chun Tsai, Chang-Wei Hsieh