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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i4.20
pages 345-355

Royal Sun Medicinal Mushroom Agaricus brasiliensis (Higher Basidiomycetes) and the Attenuation of Pulmonary Inflammation Induced by 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK)

Carolina Croccia
University Centre for Cancer Control, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Agnaldo Jose Lopes
University Centre for Cancer Control, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Luis Felipe Ribeiro Pinto
Department of Biochemistry, Institute of Biology Alberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ
Armando Ubirajara Oliveira Sabaa-Srur
Department of Experimental Basic Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, RJ
Luiz Carlos Aguiar Vaz
Department of Anatomical Pathology, State University of Rio de Janeiro, Rio de Janeiro, RJ
Marcele Nogueira de Sousa Trotte
Department of Anatomical Pathology, State University of Rio de Janeiro, Rio de Janeiro, RJ
Bernardo Tessarollo
University Centre for Cancer Control, State University of Rio de Janeiro, Rio de Janeiro, RJ
Aristofanes Correa Silva
Technology Centre, Federal University of Maranhao, Sao Luis, Brazil
Haroldo Jose de Matos
University Centre for Cancer Control, State University of Rio de Janeiro, Rio de Janeiro, RJ
Rodolfo Acatauassu Nunes
University Centre for Cancer Control, State University of Rio de Janeiro, Rio de Janeiro, RJ

ABSTRACT

Agaricus brasiliensis currently is one of the most studied fungi because of its nutritional and therapeutic properties as an anti-inflammatory agent and an adjuvant in cancer chemotherapy. The effects of orally administered aqueous A. brasiliensis extract (14.3- and 42.9-mg doses) on parenchymal lung damage induced by carcinogenic 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were observed in Wistar rats. NNK treatment induced pulmonary inflammation, but not lung cancer, in the rats. The lungs of animals treated with NNK showed a higher level of inflammation than those of the control group according to histopathologic examinations (P < 0.01) and kurtosis analysis (P < 0.001) of a global histogram generated from thoracic computed tomography scans. There was no significant difference in the alveolar and bronchial exudates between animals treated with a 14.3-mg dose of A. brasiliensis extract and the control without NNK. However, a significant difference was found between animals treated with NNK, received a 42.9-mg dose of A. brasiliensis (P < 0.05), and the controls not treated with NNK. We did not observe a significant difference between the kurtoses of the A. brasiliensis (14.3 mg) and control groups. However, a 42.9-mg dose of A. brasiliensis resulted in lower kurtosis values than those observed in the control group (P < 0.001). In conclusion, a low dose of A. brasiliensis was more effective in attenuating pulmonary inflammation. Similar to the histopathological results, the computed tomography scans also showed a protective effect of A. brasiliensis at the lower dose, which prevented gross pulmonary consolidation.


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