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International Journal of Medicinal Mushrooms

Impact factor: 1.357

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v19.i2.30
pages 121-125

Antibacterial Activity of Desert Truffles from Saudi Arabia Against Staphylococcus aureus and Pseudomonas aeruginosa

Domenico Schillaci
Department STEBICEF, University of Palermo, Palermo, Italy
Maria Grazia Cusimano
Department STEBICEF, University of Palermo, Palermo, Italy
Stella Maria Cascioferro
Department STEBICEF, University of Palermo, Palermo, Italy
Vita Di Stefano
Department STEBICEF, University of Palermo, Palermo, Italy
Vincenzo Arizza
Department STEBICEF, University of Palermo, Palermo, Italy; Euro Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy
Marco Chiaramonte
Department STEBICEF, University of Palermo, Palermo, Italy
Luigi Inguglia
Department STEBICEF, University of Palermo, Palermo, Italy; Euro Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy
Abdulhakim Bawadekji
Deanship of Scientific Research, Northern Border University, Arar, Saudi Arabia
Salvatore Davino
Euro Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; Department of Agricultural and Forest Sciences, University of Palermo, Palermo, Italy
Maria Letizia Gargano
Department of Agricultural and Forest Sciences, University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology, Palermo, Italy
Giuseppe Venturella
Department of Agricultural and Forest Sciences, University of Palermo, Palermo, Italy; Euro-Mediterranean Institute of Science and Technology, Palermo, Italy

ABSTRACT

Medicinal mushrooms represent an unlimited source of polysaccharides with nutritional, antitumoral, antibacterial, and immune-stimulating properties. Traditional studies of epigeous higher Basidiomycetes have recently been joined by studies of hypogeous fungi and, in particular, of so-called desert truffles. With the aim to obtain novel agents against bacteria of clinical importance, we focused on the edible desert truffle mushrooms Tirmania pinoyi, Terfezia claveryi, and Picoa juniperi as sources of new antimicrobial agents. In particular, we investigated the in vitro antibacterial activity of acid-soluble protein extracts (aqueous extracts) of these 3 species against the Gram-positive human pathogenic reference strain Staphylococcus aureus ATCC 29213 and the Gram-negative strain Pseudomonas aeruginosa ATCC 15442. The acid-soluble protein extracts of T. pinoyi and T. claveryi showed minimum inhibitory concentrations of 50 μg/mL against tested pathogens. We believe that such preliminary results are promising to obtain a valuable antibiotic alternative to fight antibiotic-resistant pathogens.