Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v11.i4.30
pages 365-373

Anti-inflammatory and Free Radical Scavenging Activities of Polysaccharide−Protein Complex Isolated from Phellinus rimosus (Berk.) Pilát (Aphyllophoromycetideae)

Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555, Kerala, India
Chakrapully R. Meera
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555
Balan Nitha
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555
Ram A. Vishwakarma
Medical Chemistry Group, Nicholas Piramal Research Centre, Nirolon Complex, Goregaon (E), Mumbai-400 063

ABSTRACT

Phellinus rimosus (Berk.) Pilát is a polypore mushroom found growing on jackfruit trees (Atrocarpus heterophyllus) in Kerala, India. Our previous investigations have demonstrated a variety of biological activities of this species. In this article, we report the anti-inflammatory and free radical scavenging activities of a polysaccharide−protein complex (PPC-Pr) isolated from the fruiting bodies of Ph. rimosus. The PPC-Pr was isolated from the hot water extract by solvent precipitation, depro-teinization, dialysis, and freeze drying. The anti-inflammatory activity of PPC-Pr was determined by carrageenan- and dextran-induced acute and formalin-induced chronic inflammatory models. The free radical scavenging activity of PPC-Pr was determined by evaluating superoxide radical, hydroxyl radical, nitric oxide, and 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical scavenging activities; inhibition of lipid peroxidation; and ferric reducing antioxidant power (FRAP). The PPC-Pr showed 75.24% and 88.28% inhibition of acute and 65.74% inhibition of chronic inflammation when treated at a concentration of 50 mg/kg body weight. PPC-Pr also showed significant hydroxyl radical scavenging activity (IC50: 430.0 ± 5.0) and lipid peroxidation-inhibiting activity (IC50: 253.3 ± 7.6). The results thus reveal that PPC-Pr possesses profound anti-inflammatory and free radical scavenging activities. The findings suggest the potential therapeutic use of the polysaccharide−protein complex (PPC-Pr) isolated from Ph. rimosus.


Articles with similar content:

Antioxidant and Anti-inflammatory Properties of New Medicinal Fungus, Auriculoscypha anacardiicola D.A.Reid et Manim. (Agaricomycetideae), from India
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 4
Kainoor K. Janardhanan, Bijesh Puthusseri, Thozhuthumparambil P. Smina, Patinjareveettil Manimohan
Evaluation of Anticholinesterase and Inflammation Inhibitory Activity of Medicinal Mushroom Phellinus pini (Basidiomycetes) Fruiting Bodies
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 11
Tae Soo Lee, Jaehyuk Choi, Jae Kwang Kim, Trung Kien Nguyen, Kyung Hoan Im
Antioxidative and Inhibitory Effects of the Fruiting Body of Black Lingzhi Mushroom, Amauroderma rugosum (Agaricomycetes), on LDL Oxidation and HMG-CoA Reductase Activity
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 9
Norhaniza Aminudin, Noorlidah Abdullah, Chan Kam Seng
Antioxidant and Immunomodulating Activities of Exo-and Endopolysaccharide Fractions from Submerged Mycelia Cultures of Culinary-Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 3
Karthik Marripudi, Cheang Khoo, Sundar Rao Koyyalamudi, Jong Pil Park, Jin Hee Kim, Sang-Chul Jeong, Chi-Hyun Song, J. Margaret Hughes, Trevor Bailey
Medicinal Mushroom Cracked-Cap Polypore, Phellinus rimosus (Higher Basidiomycetes) Attenuates Acute Ethanol-Induced Lipid Peroxidation in Mice
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 11
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan