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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v1.i2.100
pages 191-194

Early Historic Cancer Chemotherapy Work Involving Basidiomycetous Mushrooms

Paul A. Volz
East Michigan Mycology Associates 1805 Jackson Avenue Ann Arbor, MI 48103-4039; and North Florida Mycology Associates, 4500 Silverberry Court, Jacksonville, FL 32224-6836, USA


Boletus edulis Bull.: Pers. Fr. and Calvatia (Langermannia) gigantea (Batch: Pers.) Lloyd are two of the first species of basidiomycetous fungi in early cancer chemotherapy that were found to produce antitumor agents during the 1950s and 1960s. The compounds advanced only to the test phase in the treatment of cancer. Various assay methods were developed using cell, tissue, and microbial systems designed to identify potential antitumor agents. New compounds more specific, efficient, and less toxic in the eradication of various cancer forms remain unknown and will be discovered in the future. Cancer treatment may gain much progress from compounds produced by Basidiomycetes. However, much different and more complete cancer therapy and pretreatment unknown today may be common methods of cancer eradication and vaccination for the future.

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