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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v1.i2.70
pages 173-180

Effects of Higher Basidiomycetes Mushrooms on the Hippocampal Slices in Rats

Mykhaylo Moldavan
Oregon Health and Science University
Anna A. Grodzinskaya
Department of Spore Plants, M. G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, Tereshchenkivska str. 2, Kiev, GSP-1, 01601, Ukraine
Solomon P. Wasser
International Centre for Biotechnology and Biodiversity of Fungi Institute of Evolution and Faculty of Natural Sciences University of Haifa, Mt. Carmel, Haifa 31905, Israel
Victor M. Storozhuk
Department of Brain Physiology, A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Bogomoltza str. 4, Kiev 01024

ABSTRACT

Effects of water and ethanol extracts on spike activity of 28 neurons from the hippocampal stratum pyramidale (CA1 region) were studied in nine higher Basidiomycetes species: Boletus edulis (Bull.: Fr.), Xerocomus badius Fr., Lentinus edodes (Berk.) Sing., Lactarius turpis (Weinm.) Fr., Amanita muscaria (L.: Fr.) Hook., Stropharia aeruginosa (Curt.: Fr.) Quel., Armillariella mellea (Vahl.: Fr.) P. Karst, Hypholoma fasciculare (Huds.: Fr.) Kumm., and Piptoporus betulinus (Bull.: Fr.) P. Karst. Lactarius turpis and Lentinus edodes extracts caused the neuron excitation; S. aeruginosa, H. fasciculare, and P. betulinus extracts caused excitation or inhibition; A. muscaria, B. edulis, X. badius, and A. mellea clearly expressed inhibition responses. Extracts of A. muscaria rarely caused excitation or inhibition−excitation responses. Whether the nature of the responses was inhibitory or excitatory was not associated with the extract concentration. Neuron responses occurred only with the application of extracts in the majority of the studied species. In some cases the neuron excitation was also manifest after the termination of application of extracts of L. edodes, A. mellea, P. betulinus (for 1−5 min.) and especially A. muscaria when inhibition or excitation lasted for 6 to 12 min.


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