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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Anti-inflammatory Activity of Mycelial Extracts from Medicinal Mushrooms

Volume 16, Issue 4, 2014, pp. 319-325
DOI: 10.1615/IntJMedMushrooms.v16.i4.20
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ABSTRACT

Medicinal mushrooms have been essential components of traditional Chinese herbal medicines for thousands of years, and they protect against diverse health-related conditions. The components responsible for their anti-inflammatory activity have yet to be fully studied. This study investigates the anti-inflammatory activity of n-hexane, chloroform, ethyl acetate, and methanol extracts of mycelia in submerged culture from 5 commercially available medicinal mushrooms, namely Cephalosporium sinensis, Cordyceps mortierella, Hericium erinaceus, Ganoderma lucidum, and Armillaria mellea. MTT colorimetric assay was applied to measure the cytotoxic effects of different extracts. Their anti-inflammatory activities were evaluated via inhibition against production of lipopolysaccharide (LPS)-induced nitric oxide (NO) in murine macrophage-like cell line RAW264.7 cells. Of the 20 extracts, n-hexane, chloroform, ethyl acetate, and methanol extracts from C. sinensis, C. mortierella, and G. lucidum; chloroform extracts from H. erinaceus and A. mellea; and ethyl acetate extracts from A. mellea at nontoxic concentrations (<300 μg/mL) dose-dependently inhibited LPS-induced NO production. Among them, the chloroform extract from G. lucidum was the most effective inhibitor, with the lowest half maximal inhibitory concentration (64.09 ± 6.29 μg/mL) of the LPS-induced NO production. These results indicate that extracts from medicinal mushrooms exhibited anti-inflammatory activity that might be attributable to the inhibition of NO generation and can therefore be considered a useful therapeutic and preventive approach to various inflammation-related diseases.

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  1. Zhou Zhongkai, Ren Xiaochong, Jiang Yumei, Zhang Qin, Zhang Min, Strappe Padraig, Blanchard Chris, Responses of fecal bacterial communities to resistant starch intervention in diabetic rats, Starch - Stärke, 68, 9-10, 2016. Crossref

  2. Zhang Jiao-Jiao, Li Ya, Zhou Tong, Xu Dong-Ping, Zhang Pei, Li Sha, Li Hua-Bin, Bioactivities and Health Benefits of Mushrooms Mainly from China, Molecules, 21, 7, 2016. Crossref

  3. Wu Jingna, Liu Zhiyu, Su Jie, Pan Nan, Song Qiuling, Anti-inflammatory activity of 3β-hydroxycholest-5-en-7-one isolated from Hippocampus trimaculatus leach via inhibiting iNOS, TNF-α, and 1L-1β of LPS induced RAW 264.7 macrophage cells, Food & Function, 8, 2, 2017. Crossref

  4. Geng Yan, Zhu Shuiling, Cheng Peng, Lu Zhen-Ming, Xu Hong-Yu, Shi Jin-Song, Xu Zheng-Hong, Bioassay-guided fractionation of ethyl acetate extract from Armillaria mellea attenuates inflammatory response in lipopolysaccharide (LPS) stimulated BV-2 microglia, Phytomedicine, 26, 2017. Crossref

  5. Ernst Edzard, Medicines and Oral Treatments, in Alternative Medicine, 2019. Crossref

  6. Ernst Edzard, Überbegriffe, in Heilung oder Humbug?, 2021. Crossref

  7. Lai Ying-Jang, Hsu Kai-Di, Huang Tzu-Jung, Hsieh Chang-Wei, Chan Yu-Hin, Cheng Kuan-Chen, Anti-Melanogenic Effect from Submerged Mycelial Cultures of Ganoderma weberianum, Mycobiology, 47, 1, 2019. Crossref

  8. Wu Jing, Kawagishi Hirokazu, Plant growth regulators from mushrooms, The Journal of Antibiotics, 73, 10, 2020. Crossref

  9. Reddy M. Damoder, Kobori Hajime, Mori Takumi, Wu Jing, Kawagishi Hirokazu, Watkins E. Blake, Gram-Scale, Stereoselective Synthesis and Biological Evaluation of (+)-Armillariol C, Journal of Natural Products, 80, 9, 2017. Crossref

  10. Boufadi Mokhtaria Yasmina, Soubhye Jalal, Van Antwerpen Pierre, Anti‐inflammatory, antioxidant effects, and bioaccessibility of Tigzirt propolis, Journal of Food Biochemistry, 45, 4, 2021. Crossref

  11. Lin Yu-En, Wang Hsiang-Lan, Lu Kuan-Hung, Huang Yun-Ju, Panyod Suraphan, Liu Wei-Ting, Yang Shu-Hui, Chen Mei-Hsing, Lu Yun-Shen, Sheen Lee-Yan, Water extract of Armillaria mellea (Vahl) P. Kumm. Alleviates the depression-like behaviors in acute- and chronic mild stress-induced rodent models via anti-inflammatory action, Journal of Ethnopharmacology, 265, 2021. Crossref

  12. Yang Shang-Yu, Fang Chi-Jung, Chen Yu-Wen, Chen Wan-Ping, Lee Li-Ya, Chen Chin-Chu, Lin Yen-You, Liu Shan-Chi, Tsai Chun-Hao, Huang Wei-Chien, Wu Yang-Chang, Tang Chih-Hsin, Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis, Nutrients, 14, 13, 2022. Crossref

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