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International Journal of Medicinal Mushrooms

Impact factor: 1.357

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v16.i4.50
pages 345-354

Wound Healing Activity of an Aqueous Extract of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes)

Asheesh Gupta
Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Timarpur, Delhi, India
Vandana Kirar
Defence Institute of Physiology and Allied Sciences, DRDO, Timarpur, Delhi, India
Gaurav Kr. Keshri
Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Timarpur, Delhi, India
Shefali Gola
Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Timarpur, Delhi, India
Anju Yadav
Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Timarpur, Delhi, India
Prem Singh Negi
Defence Agricultural Research Laboratory, Pithoragarh, Uttarakhand, 262 501 India ; Defence Institute of Bio-Energy Research, Haldwani, India
Kshipra Misra
Defence Institute of Physiology and Allied Sciences, DRDO, Timarpur, Delhi, India

ABSTRACT

The Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes) is popular because of its health-promoting properties. The effects of G. lucidum extract on cancer, hypertension, hypercholesterolemia, and hepatitis have been reported by many researchers. This investigation was undertaken to evaluate the healing efficacy of an aqueous lyophilized extract of G. lucidum from the Indian Himalayan region on dermal excision wound in experimental rats. The extract used in the study was found to be rich in total polyphenol and flavonoid contents. The healing efficacy was comparatively assessed with a reference povidone-iodine ointment. The G. lucidum extract showed significant enhanced healing activity, evidenced by an increase in wound contraction, collagen accumulation (hydroxyproline), hexosamine, and total protein contents. Histopathological findings further supported the biochemical indices. The results suggest that aqueous lyophilized extract of G. lucidum possesses significant wound-healing activity.