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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Chemopreventive and Tumoricidal Properties of Ling Zhi Mushroom Ganoderma lucidum (W. Curt.:Fr.) Lloyd (Aphyllophoromycetideae). Part I. Preclinical and Clinical Studies (Review)

Volume 6, Issue 2, 2004, 12 pages
DOI: 10.1615/IntJMedMushr.v6.i2.10
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ABSTRACT

There is an increasing interest in identifying effective and safe constituents from medicinal mushrooms for cancer prevention and treatment. Ganoderma lucidum has been used for this purpose, which is given as a single agent, or in combination with herbs or synthetic chemotherapeutic agents. Various polysaccharides (in particular β-D-glucans and glycoproteins) and triterpenoids have been found to be the major active constituents responsible for the chemopreventive and tumoricidal activity of G. lucidum. These compounds exerted promising cancer preventive and anticancer activity in animal (mouse and rat) studies. However, randomized, placebo-controlled, and multicenter clinical studies using G. lucidum have rarely been reported. In a randomized, placebo-controlled clinical study, 38 (26.6%) of 143 cancer patients had stable disease for 12 weeks or more (range, 12−50 weeks) when treated with Ganoply (a G. lucidum polysaccharide extract) orally at 1800 mg three times daily for 12 weeks. Palliative effects on cancer-related symptoms, such as sweating and insomnia, have been observed in many patients. Ganopoly was well tolerated, with five moderate adverse events recorded. These initial findings indicate that G. lucidum may represent a practical and promising approach for cancer prevention and cancer treatment. Further studies are required to establish the relationship between G. lucidum intake dose and cancer risks and to investigate the efficacy and safety when used alone or in combination with chemotherapy.

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  1. Connolly Joseph D., Hill Robert A., Triterpenoids, Natural Product Reports, 24, 2, 2007. Crossref

  2. Yuen John W. M., Gohel Mayur Danny I., Anticancer Effects of Ganoderma lucidum: A Review of Scientific Evidence, Nutrition and Cancer, 53, 1, 2005. Crossref

  3. Weng Chia-Jui, Yen Gow-Chin, The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis, Clinical & Experimental Metastasis, 27, 5, 2010. Crossref

  4. Yuen J.W.M., Gohel M.D.I., Ng C.F., The differential immunological activities of Ganoderma lucidum on human pre-cancerous uroepithelial cells, Journal of Ethnopharmacology, 135, 3, 2011. Crossref

  5. Yuen J.W.M., Gohel M.D.I., The dual roles of Ganoderma antioxidants on urothelial cell DNA under carcinogenic attack, Journal of Ethnopharmacology, 118, 2, 2008. Crossref

  6. Lakshmi B., Ajith T.A., Jose Nayana, Janardhanan K.K., Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene, Journal of Ethnopharmacology, 107, 2, 2006. Crossref

  7. Pillai Thulasi G., Nair Cherupally Krishnan Krishnan, Janardhanan K.K., Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo, Environmental Toxicology and Pharmacology, 26, 1, 2008. Crossref

  8. Leskosek-Cukalovic I., Despotovic S., Lakic N., Niksic M., Nedovic V., Tesevic V., Ganoderma lucidum — Medical mushroom as a raw material for beer with enhanced functional properties, Food Research International, 43, 9, 2010. Crossref

  9. Zhao Wei, Jiang Xuejun, Deng Wenwen, Lai Yanhao, Wu Mei, Zhang Zunzhen, Antioxidant activities of Ganoderma lucidum polysaccharides and their role on DNA damage in mice induced by cobalt-60 gamma-irradiation, Food and Chemical Toxicology, 50, 2, 2012. Crossref

  10. Jin Xingzhong, Ruiz Beguerie Julieta, Sze Daniel Man-yeun, Chan Godfrey CF, Jin Xingzhong, Ganoderma lucidum(Reishi mushroom) for cancer treatment, in Cochrane Database of Systematic Reviews, 2012. Crossref

  11. Ferreira Isabel C.F.R., Heleno Sandrina A., Reis Filipa S., Stojkovic Dejan, Queiroz Maria João R.P., Vasconcelos M. Helena, Sokovic Marina, Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities, Phytochemistry, 114, 2015. Crossref

  12. Singdevsachan Sameer Kumar, Patra Jayanta Kumar, Tayung Kumananda, Thatoi Hrudayanath, Chemical Constituents, Antioxidative and Antibacterial Properties of Medicinal Mushrooms Collected from Similipal Biosphere Reserve, Odisha, India, Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, 87, 2, 2017. Crossref

  13. Zhao Ding, Li Jing-Song, Suen William, Chang Ming-Wei, Huang Jie, Preparation and characterization of Ganoderma lucidum spores-loaded alginate microspheres by electrospraying, Materials Science and Engineering: C, 62, 2016. Crossref

  14. Zhou Shu-Feng, Pharmacokinetics of Anticancer Materia Medica in Humans, in Materia Medica for Various Cancers, 2, 2012. Crossref

  15. Jin Xingzhong, Ruiz Beguerie Julieta, Sze Daniel Man-yuen, Chan Godfrey CF, Ganoderma lucidum (Reishi mushroom) for cancer treatment, Cochrane Database of Systematic Reviews, 2019, 1, 2016. Crossref

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