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International Journal of Medicinal Mushrooms

Impact factor: 1.357

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v1.i4.20
pages 301-316

Antitumor and Hypoglycemic Activities of Polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetideae)

Takashi Mizuno
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 4-13-9 Seinan-Cho, Fujieda-Shi 426-0063, Japan
Cun Zhuang
Mushroom Wisdom Inc., 1 Madison Street, Building F, East Rutherford, NJ 07073, USA
Kuniaki Abe
Kyowa Engineering Co. Ltd., 1-8-5 Shinkawa, Chuo-ku, Tokyo, 104, Japan
Hidehumi Okamoto
Chihaya Co. Ltd., 10-10 Tenjinmae, Takamatsu, 760, Japan
Tadashi Kiho
Laboratory of Medical Regulations, Gifu Pharmaceutical University, Japan
Shigeo Ukai
Gifu Pharmaceutical University, 5-6-1, Gifu, 502, Japan
Sophie Leclerc
C.N.R.S., Station Biologique, Place G. Teissier, B.P 74, 29682 Roscoff cedex, France
Laurent Meijer
C.N.R.S., Station Biologique, Place G. Teissier, B.P 74, 29682 Roscoff cedex, France

ABSTRACT

Protein-containing polysaccharides from Inonotus obliquus (Chaga), sclerotia and mycelia were extracted and partially purified. They were examined as potential inhibitors of the cell cycle regulatory enzymes cdc25 and cdc2/cyclin B and for their hypoglycemic effect, and the following results were obtained. The enzyme inhibitory activity and the hypoglycemic effects in normal mice were detected in both water-soluble and water-insoluble polysaccharides. The active principles were β-glucan, heteroglucan, and their protein complexes. No clear antienzymic traits were recognized by polysaccharides prepared from mycelia, but the hypoglycemic effect maintained for 3−48 h by the injection was recognized.