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International Journal of Medicinal Mushrooms
IF: 1.211 5-Year IF: 1.394 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v2.i3.20
6 pages

Antioxidant and Antitumor Activity of Ganoderma lucidum (Curt.: Fr.) P. Karst.—Reishi (Aphyllophoromycetideae) from South India

Susan Jones
Amala Cancer Research Centre, Amala Nagar, Trichur-680553, India
Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India

ABSTRACT

Antioxidant and antitumor properties of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) from tropical South India were investigated. A methanol extract of the mushroom showed marked superoxide radical scavenging, hydroxyl radical scavenging, and lipid peroxidation inhibiting activities. The superoxide scavenging activity of the extract was significantly high. The aqueous extract also showed marked hydroxyl radical scavenging and superoxide radical scavenging activity. Hydroxyl radical scavenging activity of the extract was significantly high. However, the aqueous extract did not inhibit lipid peroxidation. Neither methanol nor aqueous extract showed any appreciable antitumor activity against ascites tumor. However, the extracts exhibited significant antitumor activity against solid tumor induced by Ehrlich's ascites carcinoma cells. The results of the investigations indicate that G. lucidum strains occurring in tropical South India possessed significant antioxidant and antitumor properties. The findings suggest the potent therapeutic use of South Indian strains of G. lucidum.