Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v11.i1.30
pages 21-28

Antiarthritic Activity of a Polysaccharide-Protein Complex Isolated from Phellinus rimosus (Berk.) Pilát (Aphyllophoromycetideae) in Freund's Complete Adjuvant−Induced Arthritic Rats

Chakrapully R. Meera
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555
Thozhuthumparambil P. Smina
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, 680 555, India
Balan Nitha
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555
John Mathew
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555, Kerala, India

ABSTRACT

Arthritis is a common disease affecting millions, and the treatments available are generally palliative. Nonsteroidal anti-inflammatory drugs (NASIDs) are widely used clinically to treat inflammatory diseases and rheumatoid arthritis. Free radicals have long been implicated in the change in connective tissues in inflammation and arthritis. Lipid-peroxide formation as well as altered levels of endogenous free-radical scavengers, such as superoxide dismutase, glutathione peroxidase, and reduced glutathione, have been considered as indirect in vivo evidence for the participation of free radicals in the progression of arthritis. A polysaccharide-protein complex (PPC-Pr) isolated from Phellinus rimosus (Berk.) Pilát growing on jack fruit trees in India was investigated to find out its inhibitory effect on Freund's complete adjuvant (FCA)-induced arthritis in rats. A significant increase in lipid-peroxide levels in the plasma of adjuvant-induced arthritic rats was observed. The antioxidant enzymes superoxide dismutase and glutathione peroxidase were elevated in adjuvant-induced rats, and reduced blood glutathione was decreased. Treatments with various concentrations of PPC-Pr modulated the above alterations produced in arthritic animals in a dose-dependent manner. The results thus suggested the therapeutic potential of PPC-Pr as a possible alternative to nonsteroidal anti-inflammatory drugs (NSAIDs) to treat inflammatory diseases and rheumatoid arthritis.


Articles with similar content:

Chemopreventive Effect of Cardamom (Elettaria cardamomum L.) Against Benzo(α)Pyrene-Induced Forestomach Papillomagenesis in Swiss Albino Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 2
Sasikumar Dhanarasu, Mo'ez Al-Islam Faris, Samir Qiblawi
Hepatoprotective Effects of Aqueous Extract from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) on α-Amanitin−Induced Liver Injury in Mice
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 4
Jinsong Hu, Xin Wu, Jun Zeng, Qiong Liao, Zuohong Chen, Rong Zhou, Ping Zhang
Protective Effect of Curcumin Against Carbofuran-Induced Toxicity in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 1
Binitha P. Purushothaman, Ramadasan Kuttan
Hepatoprotective Activity of Water Extracts from Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes) Against Tert-Butyl Hydroperoxide−Induced Oxidative Liver Injury in Primary Cultured Rat Hepatocytes
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 11
Hyung Joo Suh, Dong Ouk Noh, Yooheon Park, Ki Bae Hong
Tilianin Protects Diabetic Retina through the Modulation of Nrf2/TXNIP/NLRP3 Inflammasome Pathways
Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 1
Gaiyun Li, Tao Ma, Ximei Zhang, Yunda Zhang, Zhao Gao, Zhigang Yuan, Xiaohong Gao