Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v11.i1.30
pages 21-28

Antiarthritic Activity of a Polysaccharide-Protein Complex Isolated from Phellinus rimosus (Berk.) Pilát (Aphyllophoromycetideae) in Freund's Complete Adjuvant−Induced Arthritic Rats

Chakrapully R. Meera
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555
Thozhuthumparambil P. Smina
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, 680 555, India
Balan Nitha
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555
John Mathew
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India

ABSTRACT

Arthritis is a common disease affecting millions, and the treatments available are generally palliative. Nonsteroidal anti-inflammatory drugs (NASIDs) are widely used clinically to treat inflammatory diseases and rheumatoid arthritis. Free radicals have long been implicated in the change in connective tissues in inflammation and arthritis. Lipid-peroxide formation as well as altered levels of endogenous free-radical scavengers, such as superoxide dismutase, glutathione peroxidase, and reduced glutathione, have been considered as indirect in vivo evidence for the participation of free radicals in the progression of arthritis. A polysaccharide-protein complex (PPC-Pr) isolated from Phellinus rimosus (Berk.) Pilát growing on jack fruit trees in India was investigated to find out its inhibitory effect on Freund's complete adjuvant (FCA)-induced arthritis in rats. A significant increase in lipid-peroxide levels in the plasma of adjuvant-induced arthritic rats was observed. The antioxidant enzymes superoxide dismutase and glutathione peroxidase were elevated in adjuvant-induced rats, and reduced blood glutathione was decreased. Treatments with various concentrations of PPC-Pr modulated the above alterations produced in arthritic animals in a dose-dependent manner. The results thus suggested the therapeutic potential of PPC-Pr as a possible alternative to nonsteroidal anti-inflammatory drugs (NSAIDs) to treat inflammatory diseases and rheumatoid arthritis.


Articles with similar content:

Hepatoprotection of Gentiana scabra Extract and Polyphenols in Liver of Carbon Tetrachloride-Intoxicated Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 3
Jyun-Han Chen, Lean-Teik Ng, Huey-Jiun Ko
Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Akbar Masood, Ovais Zargar, Mohammad Afzal Zargar, Showkat Ahmad Ganie, Shajrul Amin, Parvaiz Ahmad Dar, Shayaq Ul Abeer, Rabia Hamid, Tanveer Ali Dar, Bilal Zargar
Evaluation of Anti-Nociceptive and Anti-Inflammatory Effect of Luteolin in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.37, 2018, issue 4
Kexin Du, Yuqiang Su, Xiaoying Fan, Na Li, Yan Qin, Zhonglei Zheng, Jing Liu, Rong Sun
Effect of Marine Mangrove Avicennia marina (Forssk.) Vierh Against Acetic Acid−Induced Ulcerative Colitis in Experimental Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 2
V. Vinod Prabhu, Chandrasekharan Guruvayoorappan, C.L. Victoria Rise
The Medicinal Cracked-Cap Polypore Mushroom Phellinus rimosus (Higher Basidiomycetes) Attenuates Alloxan-Induced Hyperglycemia and Oxidative Stress in Rats
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 3
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan, Kuttikkadan A. Rony, John Mathew