Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v8.i3.60
pages 245-250

Studies on Antioxidant Effects of Culinary-Medicinal Bunashimeji Mushroom Hypsizygus marmoreus (Peck) Bigel. (Agaricomycetideae)

Tsunetomo Matsuzawa
Agricultural Technology Institute of Nagano Farmers Federation 787-1 Suzaka, Suzaka-shi, Nagano 382-0084, Japan

ABSTRACT

The antioxidant effects of Hypsizygus marmoreus were investigated for peroxyl and alkoxyl radicals by ordinary, non-tumor-bearing and tumor-bearing mice. Antioxidant activity (AOA) was determined using the plasma of these mice. On one hand, the aqueous extract of H. marmoreus fruit body was found to have slight radical trapping activity for both peroxyl and alkoxyl radicals in vitro. On the other hand, when the blood plasma of mice, fed with fodder containing 5−10% of dried powders of mushroom extract, AOA was significantly augmented with aloxyl radicals. Using an HPLC post column AOA method, it was suggested that the increase of AOA in mice plasma was caused by an induction of high-molecular-weight components of the plasma, which were produced by feeding with H. marmoreus. Moreover, the amount of lipoperoxide in the mice plasma was measured as a value of thiobarbituric acid reactive substances. The in vivo effect of the intake of H. marmoreus fruit body was also investigated by plasma AOA status of tumor-bearing mice. Female DBA/2 mice, injected subcutaneously with 3-methylcholanthrene (MC), were fed for 76 weeks. It was found that the AOA of the mice with tumors was significantly higher than those of the mice without tumors. The high levels of AOA of the mice plasma were attributable to the increase of high-molecular-weight AOA components. Thus, oral administration of the fruit body of H. marmoreus exhibited potent antitumor or cancer-preventive effects and caused a significant decrease in lipid peroxide levels, which were determined as thiobarbituric acid reactive substances. These results showed that the intake of H. marmoreus fruit body could induce an antioxidant effect, and the increase of AOA in the plasma of tumor-bearing mice was an important mechanism in cancer prevention. It was also suggested that the mushroom might play a role in the decrease of lipid peroxides trough AOA induction.


Articles with similar content:

28-Day Oral Safety Evaluation of Extracellular Polysaccharopeptides Produced in Submerged Culture from the Turkey Tail Medicinal Mushroom Trametes versicolor (L.:Fr.) Pilát LH-1 in Mice
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 3
Fang-Yi Lin, Ju-Fang Teng, Chun-Hong Lai, Po-Wen Yang, Tai-Hao Hsu, Hui-Chen Lo
Effects of Total Triterpenoids Extract from Ganoderma Iucidum (Curt.: Fr.) P. Karst. (Reishi Mushroom) on Experimental Liver Injury Models Induced by Carbon Tetrachloride or D-Galactosamine in Mice
International Journal of Medicinal Mushrooms, Vol.4, 2002, issue 4
Ming-Yu Wang, Qing-Ming Che, Qiang Liu, Zhi-Bin Lin
In Vitro and In Vivo Inhibition of Helicobacter pylori by Ethanolic Extracts of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 1
Xiumin Zhang, Liping Zhang, Robert J. Maier, Ge Wang, Susan E. Maier
Antitumor Activity of Extracts from Medicinal Basidiomycetes Mushrooms
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 11
Elena Vetchinkina, Galina Maslyakova, Valentina E. Nikitina, Alla Bucharskaya, Nikita Navolokin, Artur Prilepskii, Andrey Burov, Alexandr Shirokov
Antioxidant Effects of Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes): Evidence from Animal Studies
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 10
Solomon P. Wasser, Nataliya O. Sybirna, Borys Yurkiv, Eviatar D. Nevo