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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018025309
pages 101-117

Antioxidant Action of an Aqueous Extract of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Agaricomycetes), in Rats with Adjuvant-Induced Arthritis

Aline Cristine da Silva de Souza
Post-graduate Program of Biological Sciences, State University of Maringá, Maringá, PR, Brazil
Geferson de Almeida Gonсalves
Post-graduate Program of Food Science, State University of Maringá, Maringá, PR, Brazil
Andréia Assunсão Soares
Post-graduate Program of Biological Sciences, State University of Maringá, Maringá, PR, Brazil
Anacharis B. de Sá-Nakanishi
Post-graduate Program of Biological Sciences, State University of Maringá, Maringá, PR, Brazil; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil
Ana Paula de Santi-Rampazzo
Post-graduate Program of Biological Sciences, State University of Maringá, Maringá, PR, Brazil
Maria Raquel Marсal Natali
Department of Morphological Sciences, State University of Maringá, Maringá, PR, Brazil
Rosane Marina Peralta
Post-graduate Program of Biological Sciences, State University of Maringá, Maringá, PR, Brazil; Post-graduate Program of Food Science, State University of Maringá, Maringá, PR, Brazil; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil
Adelar Bracht
Post-graduate Program of Biological Sciences, State University of Maringá, Maringá, PR, Brazil; Post-graduate Program of Food Science, State University of Maringá, Maringá, PR, Brazil; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil

ABSTRACT

The purpose of this study was to evaluate possible effects of the administration of an aqueous Agaricus brasiliensis extract on the oxidative state of the liver, brain, and plasma in adjuvant-induced arthritic rats, a model for human rheumatoid arthritis. Daily doses of 400 mg · kg-1 were administered by gavage for 23 days. This treatment produced significant diminutions in protein carbonylation and lipid damage in the liver, brain, and plasma. It also diminished the tissue reactive oxygen species and increased the antioxidant capacity of the plasma. Antioxidant defenses, which are diminished by arthritis, were improved by treatment with the A. brasiliensis extract, as revealed by preservation of the reduced glutathione and protein thiol levels and by the tendency of the activities of some antioxidant enzymes to normalize. The increased glucose-6-phosphate dehydrogenase activity was also almost normalized by the treatment. In addition, there were indications that A. brasiliensis can inhibit the initiation of structural events that can lead to hepatocyte necrosis. In conclusion, A. brasiliensis aqueous preparations can, in principle, be visualized as potential auxiliaries in the treatment of patients with rheumatoid arthritis as a result of their capacity to reduce oxidative stress. This effect was exerted in multiple organs, as can be judged from the results obtained in the liver, brain, and plasma. The continuous ingestion of A. brasiliensis as specific preparations or as a food supplement can possibly help to attenuate the systemic effects of rheumatoid arthritis and improve the quality of life of patients affected by this disease.


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