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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Immunomodulatory Effects of Extracellular β-Glucan Isolated from the King Oyster Mushroom Pleurotus eryngii (Agaricomycetes) and Its Sulfated Form on Signaling Molecules Involved in Innate Immunity

Volume 19, Issue 6, 2017, pp. 521-533
DOI: 10.1615/IntJMedMushrooms.v19.i6.40
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ABSTRACT

The aim of this study was to determine, using murine RAW 264.7 macrophages, the immunomodulatory effect of extracellular β-glucan isolated from Pleurotus eryngii (PEBG) and its sulfated derivative (PEBG-S) on signaling molecules implicated in host innate immunity. β-Glucan was extracted and purified from the mycelial culture using optimal medium concentrations. It was then chemically converted to its sulfated form. Monosaccharide composition of β-glucan was characterized with p-aminobenzoic acid ethyl ester–derivatized sugars through highperformance liquid chromatography analysis. Fourier transform infrared structural analysis showed an S=O bond at 1250 cm-1 and C-S-O binding at 815 cm-1 in PEBG-S. 13C nuclear magnetic resonance analysis showed 1,3-linked α-D-mannopyranosyl and 1,3-β-D-glucopyranosyl in PEBG-S. A concentration-dependent increase of nitric oxide production was noticed in RAW 264.7 cells treated with PEBG-S or PEBG; those treated with PEBG-S showed less cytotoxicity than those treated with PEBG. Cellular levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 were increased by PEBG and PEBG-S treatment, suggesting that they have immunomodulatory activity. Real-time polymerase chain reaction array revealed that the expression levels of nuclear factor-κB and Toll-like receptor signaling genes in cells were upregulated by PEBG and PEBG-S. Moreover, the expression of the β-glucan receptor dectin-2 was significantly upregulated by PEBG and PEBG-S treatment, reflecting immune activation through the dectin-2-Syk-(CARD9/Bcl-10/MALT1) pathway. Our results suggest that PEBG-S could be used as an effective adjuvant or immune enhancer that can be sustainably produced by recycling the by-product of mycelial culture.

CITED BY
  1. Yan Jingmin, Meng Yue, Zhang Mengshan, Zhou Xiaohuan, Cheng Hairong, Sun Lin, Zhou Yifa, A 3-O-methylated heterogalactan from Pleurotus eryngii activates macrophages, Carbohydrate Polymers, 206, 2019. Crossref

  2. Kim Sharon H, Thomas Michael J, Wu Dayong, Carman Christopher V, Ordovás José M, Meydani Mohsen, Edible Mushrooms Reduce Atherosclerosis in Ldlr−/− Mice Fed a High-Fat Diet, The Journal of Nutrition, 149, 8, 2019. Crossref

  3. Wang Jiaqi, Jin Zhao, Zhang Wenlong, Xie Xufeng, Song Ning, Lv Tianbao, Wu Dianjun, Cao Yongguo, Martins Elizabeth Angelica Leme, The preventable efficacy of β-glucan against leptospirosis, PLOS Neglected Tropical Diseases, 13, 11, 2019. Crossref

  4. Mahfuz S.U., Long S.F., Piao X.S., Role of medicinal mushroom on growth performance and physiological responses in broiler chicken, World's Poultry Science Journal, 76, 1, 2020. Crossref

  5. Ma Gaoxing, Kimatu Benard Muinde, Yang Wenjian, Pei Fei, Zhao Liyan, Du Hengjun, Su Anxiang, Hu Qiuhui, Xiao Hang, Preparation of newly identified polysaccharide from Pleurotus eryngii and its anti‐inflammation activities potential , Journal of Food Science, 85, 9, 2020. Crossref

  6. Shin Mi-Rae, Lee Ji Hye, Lee Jin A, Kim Min Ju, Park Hae-Jin, Park Byeong Wook, Seo Seung Bo, Roh Seong-Soo, Immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium, BMC Complementary Medicine and Therapies, 21, 1, 2021. Crossref

  7. Park Yong-Sung, Jang Subin, Lee Hyunkoo, Kang Suzie, Seo Hyewon, Yeon Seoyeong, Lee Dongho, Yun Cheol-Won, Identification of the Antidepressant Function of the Edible Mushroom Pleurotus eryngii, Journal of Fungi, 7, 3, 2021. Crossref

  8. Dedhia Nirali, Marathe Sandesh J., Singhal Rekha S., Food polysaccharides: A review on emerging microbial sources, bioactivities, nanoformulations and safety considerations, Carbohydrate Polymers, 287, 2022. Crossref

  9. Yin Zhenhua, Sun-Waterhouse Dongxiao, Wang Jinmei, Ma Changyang, Waterhouse Geoffrey I.N., Kang Wenyi, Polysaccharides from edible fungi Pleurotus spp.: advances and perspectives, Journal of Future Foods, 1, 2, 2021. Crossref

  10. Battaglia Valerio, Sorrentino Roberto, Verrilli Giulia, del Piano Luisa, Sorrentino Maria Cristina, Petriccione Milena, Sicignano Mariarosaria, Magri Anna, Cermola Michele, Cerrato Domenico, Lahoz Ernesto, Potential Use of Cardunculus Biomass on Pleurotus eryngii Production: Heteroglycans Content and Nutritional Properties (Preliminary Results), Foods, 12, 1, 2022. Crossref

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