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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Effects of Total Triterpenoids Extract from Ganoderma Iucidum (Curt.: Fr.) P. Karst. (Reishi Mushroom) on Experimental Liver Injury Models Induced by Carbon Tetrachloride or D-Galactosamine in Mice

Volume 4, Issue 4, 2002, 6 pages
DOI: 10.1615/IntJMedMushr.v4.i4.70
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ABSTRACT

The effect of total triterpenoids extract isolated from Ganoderma lucidum (Curt.: Fr.) P. Karst. (GT) on two different experimental liver injury models induced by carbon tetrachloride (CCl4) and D-galactosamine (D-Gal) was studied in mice. The liver triglycerides (TG), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), and serum alanine aminotransferase (ALT) were measured. The histopathological changes in the liver were assayed in mice. The results were as follows: GT (80 mg/kg) and GT2 (10, 20, 40 mg/ kg), as malotilate, were shown to significantly inhibit the increase of serum ALT and liver TG levels in the models. GT could antagonize the decrease of SOD activity and liver GSH content and inhibit the increase of the liver MDA content in the liver-injury mice induced by CCl4 or D-Gal. Also, it could improve the histopathological changes of liver injury. The results demonstrate that total triterpenoids isolated from G. lucidum have powerful protective effects against liver damage induced by CCl4 or D-Gal. Their hepato-protective effects were perhaps related to the ability to promote the activity of scavenging enzymes for hepatic free radicals in mice, and thus to raise the ability of antioxidation in mice.

CITED BY
  1. Leskosek-Cukalovic I., Despotovic S., Lakic N., Niksic M., Nedovic V., Tesevic V., Ganoderma lucidum — Medical mushroom as a raw material for beer with enhanced functional properties, Food Research International, 43, 9, 2010. Crossref

  2. Wu Jian-Guo, Kan Yong-Jun, Wu Yan-Bin, Yi Jun, Chen Ti-Qiang, Wu Jin-Zhong, Hepatoprotective effect of ganoderma triterpenoids against oxidative damage induced bytert-butyl hydroperoxide in human hepatic HepG2 cells, Pharmaceutical Biology, 54, 5, 2016. Crossref

  3. Zhao Chao, Fan Jinlin, Liu Yuanyuan, Guo Weiling, Cao Hui, Xiao Jianbo, Wang Ying, Liu Bin, Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis, Food Chemistry, 271, 2019. Crossref

  4. Lee Hyeon A, Cho Jae-Han, Afinanisa Qonita, An Gi-Hong, Han Jae-Gu, Kang Hyo Jeung, Choi Seong Ho, Seong Hyun-A, Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice, Nutrients, 12, 11, 2020. Crossref

  5. Lalmuansangi C., Zosangzuali Mary, Lalremruati Marina, Tochhawng Lalchhandami, Siama Zothan, Evaluation of the protective effects of Ganoderma applanatum against doxorubicin-induced toxicity in Dalton’s Lymphoma Ascites (DLA) bearing mice, Drug and Chemical Toxicology, 45, 3, 2022. Crossref

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