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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i4.70
6 pages

Effects of Total Triterpenoids Extract from Ganoderma Iucidum (Curt.: Fr.) P. Karst. (Reishi Mushroom) on Experimental Liver Injury Models Induced by Carbon Tetrachloride or D-Galactosamine in Mice

Zhi-Bin Lin
Department of Pharmacology, School of Basic Medical Sciences, Beijing University, Beijing 100083, P. R. China
Ming-Yu Wang
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100083. People's Republic of China
Qiang Liu
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100083. People's Republic of China
Qing-Ming Che
Department of Traditional Chinese Medicine Drugs, College of Pharmacy, Peking University, Beijing, 100083. People's Republic of China

ABSTRACT

The effect of total triterpenoids extract isolated from Ganoderma lucidum (Curt.: Fr.) P. Karst. (GT) on two different experimental liver injury models induced by carbon tetrachloride (CCl4) and D-galactosamine (D-Gal) was studied in mice. The liver triglycerides (TG), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), and serum alanine aminotransferase (ALT) were measured. The histopathological changes in the liver were assayed in mice. The results were as follows: GT (80 mg/kg) and GT2 (10, 20, 40 mg/ kg), as malotilate, were shown to significantly inhibit the increase of serum ALT and liver TG levels in the models. GT could antagonize the decrease of SOD activity and liver GSH content and inhibit the increase of the liver MDA content in the liver-injury mice induced by CCl4 or D-Gal. Also, it could improve the histopathological changes of liver injury. The results demonstrate that total triterpenoids isolated from G. lucidum have powerful protective effects against liver damage induced by CCl4 or D-Gal. Their hepato-protective effects were perhaps related to the ability to promote the activity of scavenging enzymes for hepatic free radicals in mice, and thus to raise the ability of antioxidation in mice.


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