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International Journal of Medicinal Mushrooms

Impact factor: 1.123

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i4.60
7 pages

Antioxidant, Anti-inflammatory, and Antitumor Activities of Culinary-Medicinal Mushroom Pleurotus pufmonanus (Fr.) Quel. (Agaricomycetideae)

Nayana Jose
Amala Cancer Research Centre, Amala Nagar, Thrissur 680 553, Kerala, India
Thekkuttuparambil A. Ajith
Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur, Kerala, India
Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, Kerala, India

ABSTRACT

Antioxidant, antitumor, and anti-inflammatory activities of the methanol extract of Pleurotus pulmonarius (Fr.) Quel [= P. sajor-caju (Fr.) Singer] were evaluated. The methanol extract of P. pulmonarius showed significant hydroxyl radical-scavenging and lipid peroxidation-inhibiting activities; the concentrations required for 50% inhibition (IC50) were 476.67 and 960.0 mg/mL, respectively. However, the extract did not show superoxide radical-scavenging activity. The administration of the extract caused significant regression of solid tumor at concentrations of 250, 500, and 1000 mg/kg body weight. The extract was also significantly effective in reducing paw edema induced by carrageenan and formalin at concentrations of 500 and 1000 mg/kg body weight. In both the antitumor and anti-inflammatory models, the activity of the extracts was comparable to the standard reference drugs, cisplatin and diclofenac, respectively. The results thus suggest therapeutic potential for P. pulmonarius as an antitumor and anti-inflammatory agent.