Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v10.i4.60
pages 337-344

Positive Effect of Selenium on the Immune Regulation Activity of Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae), Proteins In Vitro

Xiao-Song Hu
The College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Guanghua Zhao
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, P. R. China


The medicinal mushroom Ganoderma lucidum (Ling Zhi or Reishi) has many biological functions, including immunity-regulation activity. Selenium (Se) is an essential trace element in animals. Our previous studies showed that G. lucidum canbiotransform20%-30% of inorganic Se from substrate. Moreover, the Se was biotransformed preferentially in forms of Se-containing proteins. Therefore, it is interesting to know how selenium influences the activity of the proteins in G. lucidum. In the present study, the effects of crude proteins (SeGLPr) from Se-enriched G. lucidum (Se-G. lucidum) and a novel protein Se-GL-P purified from Se-G. lucidum on the multiplication of T- and B-lymphocyte cells and the activity of NK cells were determined in vitro, respectively. The biological activities of the two samples were compared with four other samples, including Na2SeO3, [Na2SeO3+BSA], crude proteins from regular G. lucidum (GLPr), and [Na2SeO3+GLPr], under the same conditions. Results showed that, at the same protein and Se concentration, Se-GL-P exhibited the strongest activity among six samples in promoting the multiplication of T and B cells as well as the killer activity of NK cells with a protein concentration ranging from 20 to 2000 μg/mL. Moreover, GLPr has shown immunity-regulation activity, and the incorporation of Se into the proteins apparently enhances this activity. Thus, it appears that the immune-regulation activities of both Se and the proteins from G. lucidum can be combined.