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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i3.10
pages 209-218

Evaluation of Anticonvulsant, Antidepressant-, and Anxiolytic-like Effects of an Aqueous Extract from Cultured Mycelia of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) in Mice

Katarzyna Socala
Department of Animai Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland
Dorota Nieoczym
Department of Animai Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland
Krzysztof Grzywnowicz
Department of Biochemistry, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland
Dawid Stefaniuk
Department of Biochemistry, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland
Piotr Wlaz
Department of Animai Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland

ABSTRACT

Ganoderma lucidum is a well-known medicinal mushroom with a long history of use. This study was designed to assess the anticonvulsant potential of an aqueous extract from cultured G. lucidum mycelium in 3 acute seizure models: timed intravenous pentylenetetrazole infusion, maximal electroshock seizure threshold, and 6-Hz-induced psychomotor seizure tests in mice. Moreover, antidepressant-like and anxiolytic-like effects of G. lucidum were evaluated using the forced swim test and the elevated plus maze test in mice, respectively. No changes in seizure thresholds in the intravenous pentylenetetrazole and maximal electroshock seizure threshold tests after acute treatment with G. lucidum extract (200−600 mg/kg) was observed. However, the studied extract (100−400 mg/kg) significantly increased the threshold for psychomotor seizures in the 6-Hz seizure test. In the forced swim test, G. lucidum (100−400 mg/kg) significantly reduced the duration of immobility. No anxiolytic-like or sedative effects were reported in mice pretreated with the extract (400−600 mg/kg). G. lucidum extract (50−2400 mg/kg) did not produce toxic effects in the chimney test (motor coordination) or grip-strength test (neuromuscular strength). Further studies are required to explain the neuropharmacological effects of G. lucidum and to identify its active ingredients that may affect seizure threshold, mood, or anxiety.


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