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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i6.20
pages 505-511

Developmental Toxicity Assessment of Medicinal Mushroom Antrodia cinnamomea T.T. Chang et W.N. Chou (Higher Basidiomycetes) Submerged Culture Mycelium in Rats

Tai-I Chen
Grape King Inc., 60 Sec. 3, Lung-Kang Rd, Chung-Li City 320, Taiwan
Chiao-Wen Chen
Development Center for Biotechnology, 101 Lane 169, Kang-Ning St., Xizhi District, New Taipei City 221, Taiwan
Ting-Wei Lin
Grape King Biotechnology Inc., Chung-Li City, Taiwan
Di-Sheng Wang
Development Center for Biotechnology, 101 Lane 169, Kang-Ning St., Xizhi District, New Taipei City 221, Taiwan
Chin-Chu Chen
Bioengineering Center, Grape King Bio Ltd, Taoyuan City, Taiwan; Department of Food Science, Nutrition and Nutraceutical Biotechnology, Shih Chien University, Taipei City, Taiwan; Institute of Biotechnology, National Changhua University of Education, Changhua County, Taiwan


Antrodia cinnamomea is a Taiwanese medicinal mushroom with high antioxidant and polysaccharide content. The objective of this study is to investigate developmental toxicity of A. cinnamomea in pregnant Sprague-Dawley rats. Animals were daily gavaged with A. cinnamomea mycelium at dosage levels of 0 (reverse osmosis water), 50, 150, and 500 mg/kg from gestation day (GD) 6 to 15. All dams were sacrificed on GD 20 and were subjected to cesarean section. Fetuses were examined for external, visceral, and skeletal abnormalities. All copulated females survived until the end of the study. No significant differences were recorded in body weight change, food consumption, and maternal gestational parameters. Only two fetal malformations were noted in 970 fetuses from the treatment groups. Some variations, such as enlarged fontanel, split sternebrae, absent sacral, absent caudal vertebral centra, absent thoracic centra, absent 13th−14th ribs, and fused ribs, were found during the skeletal examination, but no treatment-induced abnormalities occurred. No dose dependency was observed in any of the developmental variations. Overall observation of foetal malformations from rats given A. cinnamomea mycelium during pregnancy demonstrates that this material is not teratogenic at doses up to 500 mg/kg. It is concluded that A. cinnamomea BCRC 35398 mycelium has no teratogenic effects in female rats and is safe to be used as a functional food ingredient.

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