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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

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Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Prevents Doxorubicin-Induced Cardiotoxicity in Rats

Volume 20, Issue 8, 2018, pp. 761-774
DOI: 10.1615/IntJMedMushrooms.2018027010
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Ravindran Kalathil Veena
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555, Kerala, India
Thekkuttuparambil Ananthanarayanan Ajith
Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur-680 555, Kerala, India
Kainoor Krishnankutty Janardhanan
Amala Cancer Research Centre, Thrissur 680555,India

ABSTRACT

Doxorubicin (DOX) is an anticancer drug used extensively to treat a variety of human malignancies. DOX chemotherapy often leads to serious cardiotoxicity. We examined the ability of a Ganoderma lucidum extract (GLE) to prevent DOX-associated cardiotoxicity. DOX treatment of cardiac tissue drastically increased levels of creatine kinase (CK), lactate dehydrogenase (LDH), lipid peroxidation (thiobarbituric acid-reactive substances), advanced oxidation protein products (AOPPs), and protein carbonyls (PCOs), and significantly decreased reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activities. Administration of GLE restored CK, LDH, AOPPs, and PCOs to almost normal levels and significantly enhanced the activity of SOD, GPx, catalase, and GSH; it also downregulated lipid peroxidation. Histopathological observations, hematology profiles, and electrocardiography parameters supported the protective effect of GLE against cardiotoxicity associated with DOX treatment.

KEY WORDS: antioxidants, cardiotoxicity, doxorubicin, free radicals, Ganoderma lucidum, medicinal mushrooms
CITED BY

  1. Chen Lihua, Abulizi Abudumijiti, Li Min, Protective Effect of Ganoderma (Lingzhi) on Radiation and Chemotherapy, in Ganoderma and Health, 1182, 2019. Crossref

  2. Kushairi , Phan , Sabaratnam , David , Naidu , Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia, Antioxidants, 8, 8, 2019. Crossref

  3. Chang Wei-Ting, Gao Zi-Han, Lo Yi-Ching, Wu Sheng-Nan, Evidence for Effective Inhibitory Actions on Hyperpolarization-Activated Cation Current Caused by Ganoderma Triterpenoids, the Main Active Constitutents of Ganoderma Spores, Molecules, 24, 23, 2019. Crossref

  4. Salvatore Maria Michela, De Gregorio Vincenza, Gallo Monica, Corsaro Maria Michela, Casillo Angela, Vecchione Raffaele, Andolfi Anna, Naviglio Daniele, Netti Paolo Antonio, Evaluation of Two Extraction Methods for the Analysis of Hydrophilic Low Molecular Weight Compounds from Ganoderma lucidum Spores and Antiproliferative Activity on Human Cell Lines, Applied Sciences, 10, 11, 2020. Crossref

  5. Koss-Mikołajczyk Izabela, Todorovic Vanja, Sobajic Sladjana, Mahajna Jamal, Gerić Marko, Tur Josep A., Bartoszek Agnieszka, Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review, International Journal of Molecular Sciences, 22, 18, 2021. Crossref

  6. Lalmuansangi C., Zosangzuali Mary, Lalremruati Marina, Tochhawng Lalchhandami, Siama Zothan, Evaluation of the protective effects of Ganoderma applanatum against doxorubicin-induced toxicity in Dalton’s Lymphoma Ascites (DLA) bearing mice, Drug and Chemical Toxicology, 45, 3, 2022. Crossref

  7. Li Jingjing, Cheng Yanfen, Li Renkai, Wu Xiaoping, Zheng Chengwen, Shiu Polly Ho-Ting, Chan Jacqueline Cho-Ki, Rangsinth Panthakarn, Liu Conghui, Leung Susan Wai-Sum, Lee Simon Ming-Yuen, Zhang Chen, Fu Chaomei, Zhang Jinming, Cheung Timothy Man-Yau, Leung George Pak-Heng, Liang Shao, Protective Effects of Amauroderma rugosum on Doxorubicin-Induced Cardiotoxicity through Suppressing Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Activating Akt/mTOR and Nrf2/HO-1 Signaling Pathways, Oxidative Medicine and Cellular Longevity, 2022, 2022. Crossref

  8. Das Sneha , Janardhanan Kainoor Krishnankutty, Thampi B. S. Harikumaran , Bioactive Extract of Morel Mushroom, Morchella esculenta (Ascomycota) Attenuates Doxorubicin-Induced Oxidative Stress Leading to Myocardial Injury , International Journal of Medicinal Mushrooms, 24, 8, 2022. Crossref

  9. Khairnar Shraddha I., Kulkarni Yogesh A., Singh Kavita, Cardiotoxicity linked to anticancer agents and cardioprotective strategy, Archives of Pharmacal Research, 45, 10, 2022. Crossref

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