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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2020036354
Forthcoming Article

Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) Ameliorates Non-spatial Learning and Memory Deficits in Rats with Hypercholesterolemia and Alzheimer’s Disease

Mohammad Azizur Rahman
Jahangirnagar University
Shahdat Hossain
Jahangirnagar University
Norhaniza Aminudin
University of Malaya
Noorlidah Abdullah
University of Malaya

ABSTRACT

Alzheimer’s Disease (AD) is the leading neuro-degenerative disorder affecting memory and learning of the aged people. Hypercholesterolemia had been implicated as one of the stark hallmarks of AD. Recent AD control guidelines have suggested lifestyle modification to slow down the progression of AD. In this regard, medicinal mushroom Ganoderma lucidum, seems apt. In the present study, hot water extract of G. lucidum (200 mg/kg body weight)vhad been fed to the hypercholesterolemic and AD model rats for 8 weeks. Non-spatial memory and learning abilities of the model animals had been assessed using novel object recognition (NOR) test, rota rod test and locomotor/open field test. Then, the animals had been sacrificed and transmission electron micrograph (TEM) view of the hippocampal neurons had been assessed. In all the non-spatial memory and learning tests, the G. lucidum HWE fed rats performed better indicating improved memory and learning abilities. TEM view showed regular arrangement of the neurons in the G. lucidum HWE fed rats compared with those of the deranged arrangement of the AD rats. Ganoderma lucidum might have aided in restoring the memory and learning abilities of the AD model animals through maintaining neuronal structure and function. Thus, G. lucidum could be suggested as a medico-therapeutic agent against AD.