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International Journal of Fluid Mechanics Research
ESCI SJR: 0.22 SNIP: 0.446 CiteScore™: 0.5

ISSN Print: 2152-5102
ISSN Online: 2152-5110

International Journal of Fluid Mechanics Research

DOI: 10.1615/InterJFluidMechRes.v25.i1-3.150
pages 181-188

Mass Transport Effects on Coronary Flow and Left Ventricular Mechanics

D. Zinemanas
The Julius Silver Institute, Department of Biomedical Engineering, The Heart System Research Center, Technion-Israel Institute of Technology, Haifa, Israel
Rafael Beyar
The Julius Silver Institute, Department of Biomedical Engineering, The Heart System Research Center, Technion-Israel Institute of Technology, Haifa, Israel
Samuel Sideman
Departments of Chemical and Biomedical Engineering The Julius Silver Institute of Biomedical Engineering Technion-Israel Institute of Technology, Haifa 32000, Israel

ABSTRACT

The contractions of the left ventricle (LV) of the heart maintain the blood flow through the body's organs, including the coronary arteries which nourish the contracting and relaxing heart muscle. The effects of fluid and mass transport inside the muscle on the LV mechanics and coronary flow are demonstrated through the model simulation of the LV response to a step change in blood osmolality and the blockage of the lymphatic outflow. An integrated LV model, that takes into account the myocardial mechanics, the coronary flow, and the fluid and mass transport, is used in the analysis. The results show that fluid and mass transport have important effects on the myocardial mechanics and the coronary flow.


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