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Critical Reviews™ in Neurobiology

ISSN Print: 0892-0915

Critical Reviews™ in Neurobiology

DOI: 10.1615/CritRevNeurobiol.v16.i3.10
pages 187-224

Glutamate Receptor Gating

Kevin Erreger
Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia, USA
Philip E. Chen
Division of Neuroscience, University of Edinburgh, Edinburgh, UK
David J. A. Wyllie
Division of Neuroscience, University of Edinburgh, Edinburgh, UK
Stephen F. Traynelis
Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia, USA

ABSTRACT

Ionotropic glutamate receptors (iGluRs) mediate the vast majority of fast excitatory synaptic transmissions within the mammalian central nervous system (CNS). As for other ion channel protein families, there has been astounding progress in recent years in elucidating the details of protein structure through the crystallization of at least part of the ion channel protein complex. The result is a new framework for the interpretation of both classic and emerging functional data. Here we summarize, compare, and contrast recent findings for the AMPA, kainate, and NMDA subtypes of glutamate receptor ion channels, with an emphasis on the functional and structural aspects of how agonist binding controls channel gating.