Library Subscription: Guest
Home Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Neurobiology

ISSN Print: 0892-0915

Critical Reviews™ in Neurobiology

DOI: 10.1615/CritRevNeurobiol.v16.i12.20
pages 25-32

GABA, Reelin, and the Neurodevelopmental Hypothesis of Schizophrenia

Hector J. Caruncho
Departments of Cell Biology, University of Santiago de Compostela, Galicia, Spain
Iria G. Dopeso-Reyes
Departments of Cell Biology, University of Santiago de Compostela, Galicia, Spain
M. Isabel Loza
Departments Pharmacology, University of Santiago de Compostela, Galicia, Spain
Miguel A. Rodriguez
Departments of Cell Biology, University of Santiago de Compostela, Galicia, Spain

ABSTRACT

The GABA—reelin cortical connection (i.e., the expression and secretion of reelin by GABAergic cortical neurons) has been shown to function not only in the adult cortex but also during tangential migration of GABAergic neuroblasts. Therefore, it is of interest to focus on the possibility that a synergic action of these compounds (understood as a topobiological effect, implying place- and time-dependent interactions) may have important implications in regulating developmental processes such as neuronal migration, dendritic sprouting, synaptogenesis, and axon pruning, as well as being involved in regulation of synaptic plasticity trough life. The present review summarizes the actual knowledge in this field and discusses the possible importance that a dysregulation of GABAergic and reelin systems may have as vulnerability factors for the etiology and pathophysiology of schizophrenia.