RT Journal Article
ID 07a1af18117743ea
A1 Luchini, Claudio
A1 Nottegar, Alessia
T1 The Roles of Chromatin Remodeling Genes in Pancreatic-Biliary Malignancies
JF Critical Reviews™ in Oncogenesis
JO CRO
YR 2017
FD 2018-03-20
VO 22
IS 5-6
SP 471
OP 479
K1 ARID1A
K1 BAP1
K1 PBRM1
K1 SWI/SNF
K1 chromatin
K1 pancreas
K1 cholangiocarcinoma
K1 oncogenesis
AB Recent studies have definitively established that chromatin remodeling is a crucial epigenetic mechanism
not only in physiological conditions but also in influencing cancer biology. It is a dynamic process in which the
chromatin, the functional entity of DNA, can undergo specific modifications by obtaining transcriptional activation or transcriptional silencing. One of the most important recent discoveries in cancer genetics and genomics is that the genes involved in the establishment of chromatin structure, the so called chromatin remodelers, are frequently mutated in different types of human cancer. This review aims to summarize the main novelties related to this topic, describing also the contribution of such genes during oncogenesis. Particularly, we focus on the switch/sucrose non-fermentable complexes and on three of the most important chromatin remodeling genes in biliary and pancreatic
cancer: ARID1A, PBRM1, and BAP1.
PB Begell House
LK https://www.dl.begellhouse.com/journals/439f422d0783386a,5fec323e07ab6bc2,07a1af18117743ea.html