RT Journal Article ID 07a1af18117743ea A1 Luchini, Claudio A1 Nottegar, Alessia T1 The Roles of Chromatin Remodeling Genes in Pancreatic-Biliary Malignancies JF Critical Reviews™ in Oncogenesis JO CRO YR 2017 FD 2018-03-20 VO 22 IS 5-6 SP 471 OP 479 K1 ARID1A K1 BAP1 K1 PBRM1 K1 SWI/SNF K1 chromatin K1 pancreas K1 cholangiocarcinoma K1 oncogenesis AB Recent studies have definitively established that chromatin remodeling is a crucial epigenetic mechanism not only in physiological conditions but also in influencing cancer biology. It is a dynamic process in which the chromatin, the functional entity of DNA, can undergo specific modifications by obtaining transcriptional activation or transcriptional silencing. One of the most important recent discoveries in cancer genetics and genomics is that the genes involved in the establishment of chromatin structure, the so called chromatin remodelers, are frequently mutated in different types of human cancer. This review aims to summarize the main novelties related to this topic, describing also the contribution of such genes during oncogenesis. Particularly, we focus on the switch/sucrose non-fermentable complexes and on three of the most important chromatin remodeling genes in biliary and pancreatic cancer: ARID1A, PBRM1, and BAP1. PB Begell House LK https://www.dl.begellhouse.com/journals/439f422d0783386a,5fec323e07ab6bc2,07a1af18117743ea.html