RT Journal Article ID 08d8dc1e45e93aa2 A1 Saber-Samandari, Samaneh A1 Nezafati, Nader A1 Saber-Samandari, Saeed T1 The Effective Role of Hydroxyapatite Based Composites in Anticancer Drug Delivery Systems JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2016 FD 2016-03-30 VO 33 IS 1 SP 41 OP 75 K1 cancer K1 chemotherapy K1 composites K1 drug delivery K1 hydroxyapatite AB Tumors consist of a heterogeneous population of cancer cells carrying multiple genetic mutations. During the past few decades, efforts have focused on curing cancer using various methods. However, traditional cancer therapies still carry some drawbacks, such as limited application for only a few cancer types, killing of normal cells, poor specificity, and associated toxicity. To overcome these disadvantages, drug-delivery methods that emphasize biomaterials have been developed and applied to optimize cancer treatments. Hydroxyapatite (HAP) is a biocompatible inorganic material that can be applied in biomedical drug-delivery applications. This review discusses the features and properties of HAP that make it an effective biomaterial and provides a comprehensive summary of recent studies in which HAP and composites containing HAP were applied as anticancer drug carriers. We believe that HAP-based composites show great promise for cancer treatment using controlled release of therapeutic agents, leading to enhanced efficiency, selective release of drugs, and prohibition of cancer cell proliferation. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,7625a1812630d890,08d8dc1e45e93aa2.html