RT Journal Article
ID 093652fc6e9c0ef2
A1 Laman, Jon D. 
A1 Claassen, Eric 
A1 Noelle, Randolph J. 
T1 Functions of CD40 and Its Ligand, gp39 (CD40L)
JF Critical Reviews™ in Immunology
JO CRI
YR 1996
FD 1996-06-30
VO 16
IS 1
SP 59
OP 108
K1 CD40
K1 CD40 Ligand
K1 gp39
K1 lymphocyte activation
K1 signal transduction
K1 tolerance
K1 cognate T and B cell interaction
K1 antibody
K1 isotype switching
K1 autoimmunity
K1 immunotherapy.
AB Initially, a role for the interaction between CD40, expressed on B cells, and gp39 (CD40L), expressed on activated T cells, has been defined in humoral immunity. CD40-CD40L interaction is an essential signal for B cell proliferation, expression of activation markers, immunoglobulin production, and isotype switching. CD40-CD40L interaction is also required for formation of B memory cells and germinal centers, and signaling through CD40 prevents apoptosis of germinal center B cells. Defective expression of CD40L in humans leads to an inability to produce isotypes other than IgM (hyper IgM syndrome), and to an absence of germinal centers.<br>
More recent evidence indicates an expansion of the role of the CD40-CD40L axis in cellular interactions beyond antibody formation. Induced expression of CD40 on monocytes can lead to CD40L-activated monocyte effector mechanisms. In addition, CD40-CD40L interactions are crucially involved in development of autoimmune disease in a number of animal models. CD40-CD40L interactions also impact on growth regulation of certain carcinomas. Manipulation of CD40L has also been used to develop novel strategies for long-term antigen-specific tolerization of peripheral T cells. Finally, the CD40-CD40L axis is involved in thymic selection.<br>
Following is a comprehensive overview of CD40L-CD40 interactions in physiological and pathogenic cellular responses and a discussion of the therapeutic ramifications of these interactions.

PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,3c16d2ed1a130fee,093652fc6e9c0ef2.html