RT Journal Article ID 16209f0664e4164b A1 Wood, Aaron H. D. A1 Zhang, Xiaoyu A1 Farber, Donna L. A1 Strome, Scott E. T1 CD8+ Memory T Lymphocytes from Bone Marrow— Immune Function and Therapeutic Potential JF Critical Reviews™ in Immunology JO CRI YR 2007 FD 2007-12-13 VO 27 IS 6 SP 527 OP 537 AB Immunity to previously encountered diseases is provided in large part by memory T lymphocytes, which may be subdivided based on phenotypic and functional differences, as well as the specific cellular compartments in which these cells reside. The bone marrow (BM) is a unique microenvironment that supports robust proliferation and recall responses of both “central” and “effector” memory T cells, particularly within the CD8+ T cell subset. The recent identification within human BM of a population of CD8+ effector memory T cells with hybrid phenotype and enhanced cytotoxic function has important implications for the development of future immunotherapies. Using activated BM CD8+ memory T cells for adoptive transfer or targeting such cells with tailored vaccines may improve the ability of these classic modalities to produce potent and long-lasting antigen-specific responses, ultimately leading to clinically significant control of viral and malignant diseases. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,4651b5bd268638ad,16209f0664e4164b.html