RT Journal Article
ID 16209f0664e4164b
A1 Wood, Aaron H. D.
A1 Zhang, Xiaoyu
A1 Farber, Donna L.
A1 Strome, Scott E.
T1 CD8+ Memory T Lymphocytes from Bone Marrow Immune Function and Therapeutic Potential
JF Critical Reviews™ in Immunology
JO CRI
YR 2007
FD 2007-12-13
VO 27
IS 6
SP 527
OP 537
AB Immunity to previously encountered diseases is provided in large part by memory T lymphocytes, which may be subdivided based on phenotypic and functional differences, as well as the specific cellular compartments in which these cells reside. The bone marrow (BM) is a unique microenvironment that supports robust proliferation and recall responses of both central and effector memory T cells, particularly within the CD8+ T cell subset. The recent identification within human BM of a population of CD8+ effector memory T cells with hybrid phenotype and enhanced cytotoxic function has important implications for the development of future immunotherapies. Using activated BM CD8+ memory T cells for adoptive transfer or targeting such cells with tailored vaccines may improve the ability of these classic modalities to produce potent and long-lasting antigen-specific responses, ultimately leading to clinically significant control of viral and malignant diseases.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,4651b5bd268638ad,16209f0664e4164b.html