RT Journal Article ID 1cc1932568db1269 A1 Huang, Shu-Ming A1 Chen, Jen-Yin A1 Chen, Chin-Chu A1 Su, Chih-Chung A1 Hu, Miao-Lin T1 Black Hoof Medicinal Mushroom Phellinus linteus (Agaricomycetes) Extracts Protect Against Radiation-Induced Hematopoietic Abnormality in Mice JF International Journal of Medicinal Mushrooms JO IJM YR 2016 FD 2016-08-30 VO 18 IS 5 SP 425 OP 431 K1 γ-ray radiation K1 hematologic parameters K1 medicinal mushrooms K1 Phellinus linteus extracts AB We investigated the effects of Phellinus linteus extracts (PLEs) against radiation damage in mice. First, BALB/c mice were irradiated once with γ-rays at 4, 5, 6, or 8 Gy and allowed to recover for 20 days. Results reveal that 8-Gy radiation caused death in 100% of mice on day 13, and 6-Gy radiation caused death in 86.7% of mice (13/15) at the end of the experiment, whereas 4- and 5-Gy radiation did not result in any death. We then used 5-Gy γ-ray radiation to examine the protective effects of PLEs. Mice were orally administered a PLE (500, 1000, and 1500 mg/kg) daily for 2 weeks before radiation and for 6 weeks after radiation. γ-Ray radiation significantly decreased body weight starting from week 2 after radiation. Supplementation with a median and high dose of PLE significantly restored body weights starting at weeks 5 and 3, respectively. The radiation-protective agent WR2721 (200 mg/kg intraperitoneally) restored body weights starting at week 4. White blood cells, platelets, red blood cells, and hemoglobin were significantly decreased by radiation, and PLEs (primarily at high doses) and WR2721 significantly prevented hematologic abnormality. These results suggest that PLE has potential as a radioprotective agent. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,0cbef6a12a779453,1cc1932568db1269.html