RT Journal Article ID 2577a95844abaec8 A1 Nyam, Kar Lin A1 Chang, Chia Yoong A1 Tan, Chon-Seng A1 Ng, Szu-Ting T1 Investigation of the Tiger Milk Medicinal Mushroom, Lignosus rhinocerotis (Agaricomycetes), as an Antiulcer Agent JF International Journal of Medicinal Mushrooms JO IJM YR 2016 FD 2017-01-09 VO 18 IS 12 SP 1093 OP 1104 K1 aspirin-induced ulcer K1 ethanol-induced ulcer K1 histological study K1 Lignosus rhinocerotis K1 medicinal mushrooms K1 ulcer index K1 water immersion-restraint stress-induced ulcer AB The aim of this study was to determine the antiulcer activity of Lignosus rhinocerotis in rats. A total of 48 Sprague-Dawley rats were used in ethanol-induced, aspirin-induced, and water immersion-restraint stress-induced ulcer models. Rats were equally divided into 4 groups for each model and orally administered 5 mL/kg distilled water, 20 mg/kg omeprazole, as well as 250 and 500 mg/kg of L. rhinocerotis powder. L. rhinocerotis powder at both 250 and 500 mg/kg doses demonstrated significant (P < 0.05) protection against gastric ulceration in all the induced ulcer models. Histological studies revealed severe damage and hemorrhage of gastric mucosa in the negative control group for all ulcer-induced models. The study suggests that L. rhinocerotis powder possesses dose-dependent antiulcer activity in the gastric mucosa, as ascertained grossly and histologically, compared with the negative control groups. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,57162b26264a3b98,2577a95844abaec8.html