RT Journal Article
ID 2577a95844abaec8
A1 Nyam, Kar Lin
A1 Chang, Chia Yoong
A1 Tan, Chon-Seng
A1 Ng, Szu-Ting
T1 Investigation of the Tiger Milk Medicinal Mushroom, Lignosus rhinocerotis (Agaricomycetes), as an Antiulcer Agent
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2016
FD 2017-01-09
VO 18
IS 12
SP 1093
OP 1104
K1 aspirin-induced ulcer
K1 ethanol-induced ulcer
K1 histological study
K1 Lignosus rhinocerotis
K1 medicinal mushrooms
K1 ulcer index
K1 water immersion-restraint stress-induced ulcer
AB The aim of this study was to determine the antiulcer activity of Lignosus rhinocerotis in rats. A total of 48 Sprague-Dawley rats were used in ethanol-induced, aspirin-induced, and water immersion-restraint stress-induced ulcer models. Rats were equally divided into 4 groups for each model and orally administered 5 mL/kg distilled water, 20 mg/kg omeprazole, as well as 250 and 500 mg/kg of L. rhinocerotis powder. L. rhinocerotis powder at both 250 and 500 mg/kg doses demonstrated significant (P < 0.05) protection against gastric ulceration in all the induced ulcer models. Histological studies revealed severe damage and hemorrhage of gastric mucosa in the negative control group for all ulcer-induced models. The study suggests that L. rhinocerotis powder possesses dose-dependent antiulcer activity in the gastric mucosa, as ascertained grossly and histologically, compared with the negative control groups.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,57162b26264a3b98,2577a95844abaec8.html