RT Journal Article ID 25ff707b68d49580 A1 YamaƧ, Mustafa A1 Zeytinoglu, Melih A1 Senturk, Hakan A1 Kartkaya, Kazim A1 Kanbak, Gungor A1 Bayramoglu, Gokhan A1 Oglakci, Aysegul A1 Van Griensven, Leonardus Johannes Lambertus Donatus T1 Effects of Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes), Polysaccharide Extract in Streptozotocin-Induced Diabetic Rats JF International Journal of Medicinal Mushrooms JO IJM YR 2016 FD 2016-07-12 VO 18 IS 4 SP 301 OP 311 K1 antidiabetic activity K1 medicinal mushrooms K1 Phellinus linteus K1 polysaccharide K1 rat AB In this article we report the healing effects of a Phellinus linteus fruiting body hot water extract (PLE) in streptozotocin (STZ)−induced diabetic rats. PLE was given before and after STZ. The preprotective, protective, and postprotective effects of PLE on STZ-induced oxidative stress were studied using biochemical (caspase 3 activity, cytosolic-to-lysosomal ratio of cathepsin B and L, DNA fragmentation levels), ordinary histological and immuno-histochemical investigation parameters. Following oral administration of PLE after STZ application, the serum glucose concentration significantly decreased up to 41.13% compared with the control group (P < 0.05). The hypoglycemic potential of the PLE was further supported by an increase of insulin secretion in the islets of Langerhans. In addition, the number of cells in Langerhans islets increased by 45.89% when PLE was given after STZ application. On the other hand, the use of PLE before oxidative stress could not prevent the onset of diabetes. This is, to our knowledge, the first study of the effect of application time of orally administered Ph. Linteus hot water extract on STZ-induced diabetes. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,4f8088b16a4cecb1,25ff707b68d49580.html