%0 Journal Article
%A Deng, Yu
%A Xu, Zhaofa
%A Xu, Bin
%A Liu, Wei
%A Feng, Shu
%A Yang, Tianyao
%D 2014
%I Begell House
%K Mercury; schisandrin B; green tea polyphenols; hepatotoxicity; oxidative stress
%N 4
%P 349-361
%R 10.1615/JEnvironPatholToxicolOncol.2014011859
%T Antioxidative Effects of Schidandrin B and Green Tea Polyphenols Against Mercuric Chloride-Induced Hepatotoxicity in rats
%U https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,3d6bbf6e6e579abd,26568b7e3185683c.html
%V 33
%X In the present study, we investigated the hepatoprotective effects of schisandrin B (Sch B) and
green tea polyphenols (GrTP), two natural antioxidants, against Hg hepatotoxicity. Fifty-six rats were randomly
divided into four groups of fourteen animals in each group: control group, Hg-treated group, Sch B pretreated
group, and GrTP pretreated group. HgCl2 injection increased Hg accumulation, pathological and ultrastructural
injury, lactate dehydrogenase (LDH) level, alanine transaminase (ALT) level, apoptosis, reactive
oxygen species (ROS) level, glutathione (GSH) level, and malondialdehyde (MDA) level. HgCl2 injection decreased
glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities. Sch B and GrTP protected
against Hg-induced dysfunction and liver injury by enhancing the antioxidant defense system. Our results
indicate that Sch B and GrTP exert antioxidative effects against Hg-induced hepatotoxicity in rats.
%8 2014-10-10