RT Journal Article
ID 26727ea06a420f77
A1 Bhattacharya, Sanjib
A1 Haldar, Pallab Kanti
T1 Trichosanthes dioica Fruit Extract Ameliorates Arsenic-Induced Brain Toxicity in Male Albino Rats
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2013
FD 2013-09-19
VO 32
IS 2
SP 141
OP 148
K1 arsenic toxicity
K1 Trichosanthes dioica
K1 fruit
K1 brain
K1 oxidative stress
K1 sodium arsenite
AB This study evaluated the ameliorative potential of aqueous extract of Trichosanthes dioica fruit (AQTD) against arsenic-induced toxicity in rat brain. AQTD (50 and 100 mg/kg) was administered orally to male Wistar albino rats for 20 consecutive days before oral administration of sodium arsenite (10 mg/kg) for 8 days. We then evaluated the brain biochemical parameters viz. lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, and DNA fragmentation. Pretreatment with AQTD significantly and dose dependently modulated all the antioxidative parameters and reduced DNA fragmentation in rat brain intoxicated with arsenic. These findings conclude that T. dioica fruit possesses a remarkable ameliorative effect against arsenic-induced brain toxicity in male albino rats, which is mediated by alleviation of arsenic-induced oxidative stress by multiple mechanisms.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,58992bb411ae4476,26727ea06a420f77.html