RT Journal Article
ID 26b5d707100616f2
A1 Ronnegren, Anna Lewandowska 
T1 Extracellular Vesicles as Potential Mediators of Epigenetic Reprogramming
JF Onco Therapeutics
JO OT
YR 2015
FD 2016-08-03
VO 6
IS 3-4
SP 133
OP 141
K1 cancer
K1 cellular communication
K1 DNA methylation
K1 epigenetic
K1 exosomes
K1 Extracellular vesicles
K1 histone modification
K1 microRNA
K1 microvesicles
AB Epigenetic machinery has the ability to affect tissue-specific gene expression and is essential for normal development. A heritable chromatin structure change can be the consequence of intracellular processes; however, there is a very high probability of its mediation with cellular communication. The information transfer can be obtained with many different strategies; nonetheless, extracellular vesicles (EVs) play a pivotal role in the regulation of physiological and pathological states. It has been widely proven that factors identified within exosomes and microvesicles, like non-coding RNA or proteins, have the ability to directly or indirectly affect post-translational modifications (PTM) of histones or DNA methylation. The phenotypic change driven by these molecules contributes to the regulation of cell identity, and disruption of the epigenetic machinery can lead to altered gene function and, consequently, diseases such as cancer. Because genetically unstable cancer cells tend to secrete higher amounts of extracellular vesicles that modulate the cancer microenvironment, it is very likely that this process involves epigenetic alternations. In this review, I discuss EV-dependent epigenetic reprogramming, with particular focus on the modification driven by miRNAs as well as by enzymes involved in the regulation of DNA methylation and histone modification.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2c6306423483e001,094245090d9a4c13,26b5d707100616f2.html