RT Journal Article
ID 2abe17b4476658f5
A1 Redmond, William L.
A1 Ruby, Carl E.
A1 Weinberg, Andrew D.
T1 The Role of OX40-Mediated Co-stimulation in T-Cell Activation and Survival
JF Critical Reviews™ in Immunology
JO CRI
YR 2009
FD 2009-06-16
VO 29
IS 3
SP 187
OP 201
K1 T lymphocytes
K1 OX40
K1 CD134
K1 co-stimulation
K1 memory
AB The extent of T-cell activation, proliferation, and survival that follows T-cell receptor (TCR) ligation is controlled by several factors, including the strength of TCR stimulation, the availability of prosurvival cytokines, and the presence or absence of co-stimulatory signals. In addition to engagement of the CD28 co-stimulatory receptor by its natural ligands, B7.1 (CD80) and B7.2 (CD86), recent work has begun to elucidate the mechanisms by which signaling through the OX40 (CD134) co-stimulatory receptor, a member of the tumor necrosis factor receptor (TNFR) superfamily, affects T-cell responses. Importantly, OX40 ligation has been shown to augment CD4 and CD8 T-cell clonal expansion, effector differentiation, survival, and in some cases, abrogate the suppressive activity of regulatory FoxP3<sup>&#43;</sup>CD25<sup>&#43;</sup>CD4<sup>&#43;</sup> T cells. In this review, we focus on the mechanisms regulating OX40 expression on activated T cells as well as the role of OX40-mediated co-stimulation in boosting T-cell clonal expansion, effector differentiation, and survival.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,18841dcb1a005a88,2abe17b4476658f5.html