RT Journal Article ID 2ea88866438e4087 A1 Aragones, Julian A1 Elorza, Ainara A1 Acosta-Iborra, Barbara A1 Landazuri, Manuel O. T1 Myeloid Hypoxia-Inducible Factors in Inflammatory Diseases JF Critical Reviews™ in Immunology JO CRI YR 2011 FD 2011-03-10 VO 31 IS 1 SP 1 OP 13 K1 hypoxia-inducible factor (HIF) K1 hypoxia K1 macrophages K1 inflammation AB Hypoxia inducible factors (HIF1 and HIF2) have emerged as central regulators of the activity of myeloid cells at inflammatory sites where O2 is frequently limited. Novel insights in the field have revealed that the expression of HIFs by myeloid cells is not exclusively induced by hypoxia but also in response to central inflammatory mediators independently of O2 shortage. This has substantially elevated the biological significance of HIFs in the context of inflammatory diseases. As a consequence, the loss of HIF1 or HIF2 in myeloid cells specifically compro-mises some of the processes driven by myeloid cells, such as bactericidal activity and myeloid invasion, as well as inflammation-associated detrimental consequences. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,0e645e2f1f194b46,2ea88866438e4087.html