RT Journal Article ID 323afa9647998584 A1 Ćilerdžić, Jasmina A1 Kosanic, Marijana A1 Stajić, Mirjana A1 Vukojević, Jelena A1 Ranković, Branislav T1 Species of Genus Ganoderma (Agaricomycetes) Fermentation Broth: A Novel Antioxidant and Antimicrobial Agent JF International Journal of Medicinal Mushrooms JO IJM YR 2016 FD 2016-08-30 VO 18 IS 5 SP 397 OP 404 K1 antibacterial activity K1 antifungal activity K1 antioxidative activity K1 Ganoderma applanatum K1 Ganoderma carnosum K1 Ganoderma lucidum K1 medicinal mushrooms K1 submerged cultivation AB The bioactivity of Ganoderma lucidum basidiocarps has been well documented, but there are no data on the medicinal properties of its submerged cultivation broth nor on the other species of the genus Ganoderma. Thus the aim of this study was to test the potential antimicrobial and antioxidant activity of fermentation broth obtained after submerged cultivation of G. applanatum, G. carnosum, and G. lucidum. DPPH· scavenging ability, total phenols, and flavonoid contents were measured to determine the antioxidative potential of Ganoderma spp. fermentation filtrates, whereas their antimicrobial potential was studied using the microdilution method. DPPH· scavenging activity of G. lucidum fermentation filtrates was significantly higher than that of G. applanatum and G. carnosum, with the maximum (39.67%) obtained from strain BEOFB 432. This filtrate also contained the highest concentrations of phenols (134.89 μg gallic acid equivalents/mL) and flavonoids (42.20 μg quercetin equivalent/mL). High correlations between the activity and phenol content in the extracts showed that these compounds were active components of the antioxidative activity. G. lucidum strain BEOFB 432 was the most effective antibacterial agent, whereas strain BEOFB 434 has proven to be the most effective antifungal agent. The study showed that Ganoderma spp. fermentation filtrates are novel potent antioxidative and antimicrobial agents that could be obtained more quickly and cheaper than basidiocarps. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,0cbef6a12a779453,323afa9647998584.html