%0 Journal Article %A Fadeeva, I. V. %A Filippov, Ya. Yu. %A Fomin, A. S. %A Shaposhnikov, M. E. %A Davydova, G. A. %A Antonova, O. S. %A Selezneva, I. I. %A Mikheev, A. Yu. %A Akhmetov, L. I. %A Barinov, S. M. %A Zaraisky, E. I. %A Poltavtseva, R. A. %D 2015 %I Begell House %K tricalcium phosphate ceramics, silicon-substituted, biocompatibility %N 4 %P 305-317 %R 10.1615/NanomechanicsSciTechnolIntJ.v6.i4.50 %T SYNTHESIS OF MICRO- AND NANOSIZED BIORESORBING SILICON-SUBSTITUTED TRICALCIUM PHOSPHATES FOR BONE TISSUE ENGINEERING AND THEIR BIOLOGICAL SAFETY USING MESENCHYMAL STEM CELLS %U https://www.dl.begellhouse.com/journals/11e12455066dab5d,286dcae337feeb11,34351cdb2f591632.html %V 6 %X Silicon-substituted tricalcium phosphates have been developed by the precipitation method and heterophase mechanic activation using tetraethoxysilan as a source of silicate ions. The phase composition was established to depend on the silicate concentration: the apatite phase is formed at 0.09 wt.% silicate and Whitlockite is formed when the silicate concentration increases 10 times − up to 0.90 wt.%. The inhomogeneity and surface roughness of the material increase with the silicate concentration. Increasing the content of silicon in synthesized TCPs increases their thermal stability. Ceramics from silicon-substituted TCPs does not manifest cytotoxicity, while the cell spreading on the material surfaces increases with the degree of surface development, displaying the maximum value for the TCP sample with Si 0.1 substitution. The TCP ceramics containing 0.9 wt.% silicate ions characterize a pronounced antibacterial activity to E. Coli strain, whereas ceramics from TCPs do not manifest antibacterial activity. %8 2016-10-31