%0 Journal Article %A Talanov, Sergiy O. %A Kotsuruba, Anatoliy V. %A Korkach, Yulia P. %D 2010 %I Begell House %K cerebral dopamine deficiency, cardiovascular system, reactive oxygen species %N 1 %P 17-24 %R 10.1615/IntJPhysPathophys.v1.i1.30 %T Oxidative Stress in a Cardiovascular System of Rats with Persistent Deficiency of Cerebral Dopamine %U https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,3b5b4a4141ec079d,436d00887e8edec6.html %V 1 %X Physiological significance of cardiac mitochondrial reactive oxygen species (ROS) regulation is still unknown. In the current study, mitochondrial ROS (O2 and OH) generation, stabile H2O2 and lipids peroxidation marker (malonic dialdehyde, MDA) pools, as well as pools of potent antioxidants − urea and uric acid − were determined in rat heart, miocardial mitochondria and in blood plasma and erythrocytes at low 44% and high 96% levels of cerebral dopamine-synthesis neurons destruction (by 6-hydroxidopamine treatment). In the untreated rats ROS generation, H2O2 and MDA levels were low but in rats with chronic 3−4 month deficiency of cerebral dopamine synthesis by nigro-striatal dopaminergic system ROS generation and lipids peroxidation were progressively increased. Dopamine deficiency can improve mitochondrial efficiency of oxidative phosphorylation due to oxidative stress. %8 2010-09-24