%0 Journal Article
%A Talanov, Sergiy O.
%A Kotsuruba, Anatoliy V.
%A Korkach, Yulia P.
%D 2010
%I Begell House
%K cerebral dopamine deficiency, cardiovascular system, reactive oxygen species
%N 1
%P 17-24
%R 10.1615/IntJPhysPathophys.v1.i1.30
%T Oxidative Stress in a Cardiovascular System of Rats with Persistent Deficiency of Cerebral Dopamine
%U https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,3b5b4a4141ec079d,436d00887e8edec6.html
%V 1
%X Physiological significance of cardiac mitochondrial reactive oxygen species (ROS) regulation is still unknown. In the current study, mitochondrial ROS (O2− and OH) generation, stabile H2O2 and lipids peroxidation marker (malonic dialdehyde, MDA) pools, as well as pools of potent antioxidants − urea and uric acid − were determined in rat heart, miocardial mitochondria and in blood plasma and erythrocytes at low 44% and high 96% levels of cerebral dopamine-synthesis neurons destruction (by 6-hydroxidopamine treatment). In the untreated rats ROS generation, H2O2 and MDA levels were low but in rats with chronic 3−4 month deficiency of cerebral dopamine synthesis by nigro-striatal dopaminergic system ROS generation and lipids peroxidation were progressively increased. Dopamine deficiency can improve mitochondrial efficiency of oxidative phosphorylation due to oxidative stress.
%8 2010-09-24