RT Journal Article ID 4498b1f779d74c29 A1 Kiyokawa, Etsuko A1 Mochizuki, Naoki A1 Kurata, Takeshi A1 Matsuda, Michiyuki T1 Role of Crk Oncogene Product in Physiologic Signaling JF Critical Reviews™ in Oncogenesis JO CRO YR 1997 FD 1997-12-01 VO 8 IS 4 SP 329 OP 342 K1 v-Crk K1 c-Crk K1 Crkll K1 CrkI K1 CrkL K1 oncogene K1 SH2 K1 SH3 AB v-Crk is a member of the family of adaptor-type signaling molecules that consist mostly of SH2 and SH3 domains. The cellular homologs of v-Crk includes CrkI, Crkll, and CrkL; these have been isolated from species ranging from lower vertebrates to man. Crk-family proteins are involved in a variety of signaling cascades such as those of growth factor receptor, integrin, T-cell receptor, B-cell antigen receptor, and cytokines. It has been postulated that the primary function of Crk is to recruit cytoplasmic proteins in the vicinity of tyrosine kinases through SH2-phosphotyrosine interaction. Thus, the output from Crk depends on the SH3-binding proteins, which include the C3G guanine nucleotide exchange protein for Rapl, Abl tyrosine kinase, DOCK 180, and the Sos guanine nucleotide exchange protein for Ras. The variety of the Crk-binding proteins indicate the pleiotropic function of Crk. PB Begell House LK https://www.dl.begellhouse.com/journals/439f422d0783386a,50b580557bae60ef,4498b1f779d74c29.html