RT Journal Article
ID 497adbf268f4b168
A1 Wu , Tong 
A1 Xu, Baojun (Bruce)
T1 Antidiabetic and Antioxidant Activities of Eight Medicinal Mushroom Species from China
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2015
FD 2015-02-26
VO 17
IS 2
SP 129
OP 140
K1 medicinal mushrooms
K1 <i>Ganoderma lucidum</i>
K1 &#945;-glycosidase
K1 aldose reductase
K1 antioxidant properties
K1 diabetics
AB The objective of the current study was to verify antidiabetic effects of different types of mushrooms as folk medicines in treating diabetes. The antidiabetic effects were evaluated by in vitro &#945;-glycosidase and aldose reductase (AR) inhibitory assays and antioxidant activity assay. <i>Ganoderma lucidum</i> extract exhibited the best dose-dependent inhibitory activity against &#945;-glycosidase with IC<sub>50</sub> at 4.88 mg/mL, and also exhibited aldose reductase inhibitory potential with IC<sub>50</sub> value of 9.87 mg/mL. <i>Tremella fuciformis</i> demonstrated the highest AR inhibitory activity (IC<sub>50</sub>&#61;8.39 mg/mL). Antioxidant activities of selected mushrooms were evaluated based on the total phenolic content (TPC), total flavonoids content (TFC), and DPPH free radical scavenging activity. The result showed that <i>G. lucidum</i> contained the highest TPC (39.3 mg GAE/g sample extract), TFC (15.1 mg CE/g sample extract), and the strongest DPPH free radical scavenging activity (IC<sub>50</sub>&#61;3.66 mg/mL) among the mushroom samples.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,153df053409c56bf,497adbf268f4b168.html