RT Journal Article
ID 4aefbb8a3555cf03
A1 Kalkan, Rasime
A1 Atli, Emine İkbal 
T1 The Impacts of miRNAs in Glioblastoma Progression
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2016
FD 2016-07-28
VO 26
IS 2
SP 137
OP 142
K1 miRNA
K1 GBM
K1 Glioblastoma
K1 therapy
K1 survival
AB miRNAs are short noncoding RNA sequences that cause translational repression or mRNA degradation. 
A growing number of studies have sought new biomarkers in GBM that will be important in disease progression and prognosis and as potential therapeutic targets. miRNA-profiling studies in glioblastoma patients have found that aberrant miRNA expression can be used as a target to develop new biomarkers for disease detection and for determining prognosis or therapeutic response. In evaluating the tumor or its therapeutic response, genetic abnormalities such as mutations, epigenetic abnormalities, and aberrant miRNA expressions can be useful markers. This review summarizes the known miRNAs according their therapeutic importance and their use as disease progression biomarkers.


PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,6a2f4ed758525085,4aefbb8a3555cf03.html