%0 Journal Article %A Crowell , Pamela L. %A Gould, Michael N. %D 1994 %I Begell House %K chemotherapy, terpene, isoprenylation, ras, mammary carcinogenesis %N 1 %P 1-22 %R 10.1615/CritRevOncog.v5.i1.10 %T Chemoprevention and Therapy of Cancer by d-Limonene %U https://www.dl.begellhouse.com/journals/439f422d0783386a,1241e75b759e4a2a,4bd7bcb44f767655.html %V 5 %X The naturally occurring monoterpene d-limonene has chemopreventive and chemotherapeutic activity against many rodent solid tumor types. The chemopreventive activity of limonene during initiation can be attributed to the induction of phase I and phase II enzymes, with resulting carcinogen detoxification. The chemopreventive activity of limonene during promotion/progression may be due in part to inhibition of the posttranslational isoprenylation of growth-controlling small G proteins, such as p21ras. The complete regression of mammary carcinomas by limonene appears to involve tissue redifferentiation. The multiple antitumorigenic effects of limonene are attainable at a high therapeutic ratio, suggesting that limonene and related monoterpenes may be efficacious in the chemoprevention and chemotherapy of human malignancies. %8 1994-02-20