%0 Journal Article
%A Crowell , Pamela L.
%A Gould, Michael N.
%D 1994
%I Begell House
%K chemotherapy, terpene, isoprenylation, ras, mammary carcinogenesis
%N 1
%P 1-22
%R 10.1615/CritRevOncog.v5.i1.10
%T Chemoprevention and Therapy of Cancer by d-Limonene
%U https://www.dl.begellhouse.com/journals/439f422d0783386a,1241e75b759e4a2a,4bd7bcb44f767655.html
%V 5
%X The naturally occurring monoterpene d-limonene has chemopreventive and chemotherapeutic activity against many rodent solid tumor types. The chemopreventive activity of limonene during initiation can be attributed to the induction of phase I and phase II enzymes, with resulting carcinogen detoxification. The chemopreventive activity of limonene during promotion/progression may be due in part to inhibition of the posttranslational isoprenylation of growth-controlling small G proteins, such as p21ras. The complete regression of mammary carcinomas by limonene appears to involve tissue redifferentiation. The multiple antitumorigenic effects of limonene are attainable at a high therapeutic ratio, suggesting that limonene and related monoterpenes may be efficacious in the chemoprevention and chemotherapy of human malignancies.
%8 1994-02-20